• Tissue-Specific Antioxidant Responses and PAL Gene Expression in Bread Wheat Under Drought Stress 

  Tanbakuyi, Fateme؛ Chaichi, Mehrdad؛ Razavi, Khadijeh؛ Sanjarian, Forough (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Drought stress affects crop wheat productivity by inducing biochemical changes in different tissues. Antioxidant enzymes, phenolic compounds and sugars are crucial in the plant's defense against stress. Studying ...

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• Co-Infection of Cucumber Mosaic Virus Could Stabilize Its Recombinant Coat Protein Expressed by Zucchini Yellow Mosaic Virus 

  Nassaj Hosseini, Sayed Mohsen؛ Shamsbakhsh, Masoud؛ Yeh, Shyi (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Plant viral proteins can be part of the virus particle or its components. Some viral proteins are detectable only under specific conditions, such as during co-infection with another virus, which may lead to ...

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• Introducing new inhibitors of PAICS, a de novo purine biosynthesis enzyme, through structure-based virtual screening 

  Chamani, Reyhane؛ Darvand Araghi, Mohammad Hosein (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Cancer cells need many purine nucleotides during their uncontrolled proliferation. PAICS is one of the enzymes involved in de novo purine biosynthesis. The PAICS gene is overexpressed in some types of cancer, ...

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• In vitro evaluation the cytotoxic effects of a recombinant mutated form of soluble IL-6 receptor in ovarian cancer cell line 

  Khatir, Kosar؛ aghaie, Mahmmud؛ Ghorbanhosseini, Seyedeh Sara؛ Shafiee, Fatemeh (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  AbstractBackground: IL-6 plays an important role in cancer metastasis. Therefore, it seems that interleukin-6 inhibition can act as an anticancer agent.Objectives: In this study, the anti-proliferative and IL-6 signal ...

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• The regulatory effect of human umbilical cord mesenchymal stem cells on the gut microbiota in diabetic nephropathy rats 

  Wang, Caili؛ Wu, Chengdong؛ Mi, Yan؛ Song, Jixuan؛ Zhang, Min (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Chronic inflammation is increasingly recognized as a key factor in the progression of diabetic kidney disease (DKD). By discovering that the regulation of gut microbiota plays an important role in diabetic ...

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• NNT-AS1 with Therapeutic Promise in Mycoplasma Pneumoniae Pneumonia via the Mir-410-3p/TMEM14A/Wnt/Β‑Catenin Signaling Pathway 

  Zhou, Yue؛ Yuan, Yingjuan (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  AbstractBackground: Long non-coding RNA (lncRNA) NNT-AS1 is involved in the progression of various lung and inflammatory diseases, and has been reported to be upregulated in patients with Mycoplasma pneumoniae pneumonia ...

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• Validation of the mechanism of action of TYROBP related to blood-brain barrier function in intracerebral hemorrhage by bioinformatics analysis 

  Ji, Chengyuan؛ Cheng, Dejing؛ Yang, Siyuan؛ Wang, Zhong (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Intracerebral hemorrhage (ICH) is an extremely common acute vascular disease in the elderly population with a high potential for disability and death. Objective: To analyze TYROBP related to blood-brain barrier ...

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• Synergic effects of Curcumin, Licorice, and endoscopic photodynamic therapy against helicobacter pylori by modulating the NF-κB signaling pathway 

  Dong, Xiaoling؛ Qin, Yuehong؛ Zhu, Zhenyu؛ Wen, Xiaowen؛ Wang, Shijiang؛ Gong, Weipeng؛ Song, Xilin؛ Chai, Jie؛ Abedi-Firouzjah, Razzagh؛ Liu, Kai (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Background: Helicobacter pylori (H. pylori) infection affects nearly half of the global population and is a significant contributor to gastroduodenal conditions, including gastric carcinoma. Research on herbal extracts has ...

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• Aptamers in Combination Therapies for Enhanced Radiosensitization in Cancer 

  bemidinezhad, abolfazl؛ Sarabian Tabrizi, Arsalan؛ gheybi, fatemeh؛ Abolhassani, Yasaman؛ Parsa-kondelaji, Mohammad؛ Roshani, Ramin؛ Noroozi-karimabad, Mojgan (National Institute of Genetic Engineering and Biotechnology, 2025-01-01)

  Abstract :This review explores the emerging role of aptamers in enhancing radiotherapy (RT) efficacy through their ability to target tumor sites with high specificity. Cancer, a complex disease, involves uncontrolled cell ...

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• Arbitrarily Suffixed Sequence-Specific Primer PCR for Reliable Genome Walking: Taking Genome Walkings of Levilactobacillus brevis And Rice as Examples 

  Li, Haixing؛ Wei, Cheng؛ Pan, Zhenkang؛ LIU, Xiaohua (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Genome walking has contributed to life science-related areas. Herein, we detailed a new genome walking method, nominated as arbitrarily suffixed sequence-specific primer PCR (ASP-PCR). Objectives: This study ...

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• HLAPepBinder: An Ensemble Model for The Prediction Of HLA-Peptide Binding 

  Saadat, Mahsa؛ Zare, Fatemeh؛ Masoudi-Nejad, Ali؛ Farahanchi Baradaran, Mohammad؛ Hosseinkhan, Nazanin (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Human leukocyte antigens (HLAs) play a pivotal role in orchestrating the host's immune response, offering a promising avenue with reduced adverse effects compared to conventional treatments. Cancer immunotherapies ...

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• Identification and Verification of Key Genes Associated with Temozolomide Resistance in Glioblastoma Based on Comprehensive Bioinformatics Analysis 

  Hu, Jun؛ Yang, Jingyan؛ Hu, Na؛ Shi, Zongting؛ Hu, Tiemin؛ Mi, Baohong؛ Wang, Hong؛ Chen, Weiheng (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Glioblastoma (GBM) is the most aggressive form of brain cancer, with poor prognosis despite treatments like temozolomide (TMZ). Resistance to TMZ is a significant clinical challenge, and understanding the genes ...

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• Simultaneous Expression of Recombinant Cellulase and Protease in An Indigenous Bacillus Cereus Strain 

  Farhangi, Zainab؛ Tabatabaee Yazdi, Farideh؛ Yakhchali, Bagher (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Gene manipulation has a wide array of applications in microorganisms. We can construct multifunctional bacterial strains by gene manipulation and gene editing in order to produce several industrial biomaterials ...

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• Bioinformatic Approaches for the Identification of Novel Tumor Suppressor Genes and Cancer Pathways in Renal Clear Cell Carcinoma 

  Dastsooz, Hassan؛ Mohammadisoleimani, Elham؛ Haghi-Aminjan, Hamed؛ Firoozi, Zahra؛ Mansoori, Yaser (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Received: 2023/10/21 ;    Accepted: 2024/05/15 Background: Clear cell renal cell carcinoma (ccRCC, KIRC) is the most prevalent subtype of RCC, and even with different available therapies, the average progression-free ...

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• Improving Bioplastic Production: Enhanced P(3HB-co-3HHx) Synthesis from Glucose by Using Mutant Cupriavidus necator 

  Biglari, Nazila؛ Abdeshahian, Peyman؛ Orita, Izumi؛ Fukui, Toshiaki؛ Sudesh, Kumar (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Biodegradable polyhydroxyalkanoates (PHAs) hold promises for various applications in industries ranging from packaging to biomedical engineering, highlighting the importance of this pioneering research in ...

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• The Enhancement of Potato (Solanum Tuberosum L. Cv. Odyssey) Resistance to Bacterial Soft Rot Disease Through Transformation of the Glyphosate-Resistant Gene from Dickeya Dadantii 

  Pasalari, Hossein؛ Roeintan, Amir؛ Ercişli, Sezai؛ Kahrizi, Danial؛ Hemati, Chamran (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Background: Potato cultivation ranks among the world's major crops, yet it is vulnerable to numerous diseases. The integration of glyphosate-resistance genes into potato plants allows for the direct application of glyphosate, ...

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• Recombinant Antimicrobial Peptides (rAMPs); Potential Applications in Medicine and Veterinary Medicine: A Review 

  Asghari Baghkheirati, Amir؛ Golmohammadi, reza؛ Sekhavati, Mohammad Hadi؛ Razmyar, Jamshid؛ Abyazi, Mohammad Ali (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Abstarct: Antibiotic resistance has become a major public health concern worldwide. Treatment of humans and animals is becoming increasingly challenging due to antibiotic resistance. Antibiotic-resistant bacteria can be ...

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• A Review on the Impact of Aberrant Methylation in Breast Cancer: Diagnostic, Prognostic, and Therapeutic Approaches 

  Hosseini, Majid؛ Feghhi-Najafabadi, Saba؛ Azad, Mehdi (National Institute of Genetic Engineering and Biotechnology, 2024-10-01)

  Abstract: Breast cancer (BC) is still a major global health concern, and a key factor in its pathophysiology is epigenetic abnormalities, specifically DNA methylation and histone modifications. This review offers a thorough ...

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• Genetic Diversity and Population Structure of Primary Tritipyrum Lines in Comparison with Bread Wheat Varieties and Triticale Lines using SCoT Markers 

  Rezai, Marzia؛ Seifati, S. Ebrahim؛ Tabandeh-Saravi, Afagh؛ Shahsavand Hassani, Hossein (National Institute of Genetic Engineering and Biotechnology, 2024-07-01)

  Background: Triticale and tritipyrum as a new artificial cereal were investigated as potential stress-resistant alternatives within the Triticeae tribe due to their notable adaptability to environmental stresses. Objectives: ...

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• Plant Heat Shock Proteins Are More Effective in Enhancing Recombinant Alcohol Dehydrogenase Activity than Bacterial Ones In Vitro 

  Jung, Minjae؛ Park, Yunjin؛ Ahn, Yeh-Jin (National Institute of Genetic Engineering and Biotechnology, 2024-07-01)

  Background: Recombinant proteins produced in the cell factories are used in biological research, pharmaceutical production, and biochemical and agricultural applications. Molecular chaperones, such as heat shock proteins ...

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