Volume 18, Issue 1
مرور بر اساس
ارسال های اخیر
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Directed Blocking of TGF-β Receptor I Binding Site Using Tailored Peptide Segments to Inhibit its Signaling Pathway
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind ...
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Downregulation of TMEM40 by miR-138-5p suppresses cell proliferation and mobility in clear cell renal cell carcinoma
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: Clear cell renal cell carcinoma (ccRCC) represents approximately 70% of RCC,as the most frequent histological subtype of RCC. MiR-138-5p, a tumor-related microRNA (miRNA), has been reported to ...
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Molecular Identification and Characterization of Bacillus sp. NIGAB-1 for Phenol Degradation Under Saline Conditions
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: Phenol is an aromatic pollutant in industrial wastes that in combination with salts is highly toxic for all forms of life. Phenol elimination is the foremost challenge to meet the goal of ...
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Parallelizing Assignment Problem with DNA Strands
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background:Many problems of combinatorial optimization, which are solvable only in exponential time, are known to be Non-Deterministic Polynomial hard (NP-hard). With the advent of parallel machines, new ...
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Evaluation of Gelatinolytic and Collagenolytic Activity of Fasciola hepatica Recombinant Cathepsin-L1
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: Cysteine proteases of the liver fluke, Fasciola hepatica, participate in catabolism of proteins, migration of the fluke through host tissues and combat host immune system. ...
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Downregulation of HMGB1 by miR-103a-3p Promotes Cell Proliferation, Alleviates Apoptosis and Inflammation in a Cell Model of Osteoarthritis
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains ...
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Modeling, Mutagenesis and In-silico Structural Stability Assay of the Model of Superoxide Dismutase of Lactococcus Lactis Subsp. Cremoris MG1363
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background:Characterizing the structure and function of superoxide dismutase (SOD), as an antioxidant enzyme providing opportunities for its application in food supplements. Objectives
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Greener Synthesis of Rod Shaped Zinc Oxide NPs Using Lilium ledebourii Tuber and Evaluation of Their Leishmanicidal Activity
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: NPs (NPs) with unique chemical and physical properties can be used for therapeutic purposes because of their strong antimicrobial activates. NPs have been used as an antimicrobial agents to ...
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Characterization of the Potential Probiotic Vibrio sp. V33 Antagonizing Vibrio Splendidus Based on Iron Competition
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background：Vibrio splendidusVs is an important aquaculture pathogen that can infect a broad host of marine organisms. In our previous study, an antagonistic bacterium ...
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Development and Application of an Immunocapture PCR Diagnostic Assay Based on the Monoclonal Antibody for the Detection of Shigella
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: Shigella is among the most important human pathogenic microorganisms, infecting both humans and nonhuman and causing clinically severe diarrhea. Shigella must be enriched before detection, which ...
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Construction of a Nanobodies Phage Display Library From an Escherichia coli Immunized Dromedary
(National Institute of Genetic Engineering and Biotechnology, 2020-01-01)Background: Diarrhea caused by Escherichia coli is a major cause of morbidity and mortality in young animals. Few treatment options are available, mainly antibiotic therapy increasingly limited by resistance ...
