Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis

Abstract

<b>Background:</b> To systematically summarize the association between the X-ray repair cross complementing3 (XRCC3) gene polymorphism and oral cancer susceptibility by meta-analysis. Materials and <br/><b>Methods</b>:Databases including PubMed, EMbase, CNKI, VIP and WanFang Data were searched to identify case-controlstudies concerning the association between an XRCC3 gene polymorphism and the risk of oral cancer from theinception to June 2014. Two reviewers independently screened the literature according to the criteria, extractedthe data and assessed the quality. Then meta-analysis was performed using Stata 11.0 software. <br/><b>Results</b>:Seven published case-control studies including 775 patients with oral cancer and 1922 controls were selected.Associations between the rs861539 polymorphism and overall oral cancer risk were not statistically significantin all kinds of comparison models (CT vs CC: OR=0.94, 95%CI=0.74-1.18; TT vs CC: OR=0.94, 95%CI=0.64-1.38; dominant model: OR=0.95, 95%CI=0.76-1.18; recessive model: OR=0.94, 95%CI=0.69-1.29; allele T vs C:OR=0.97, 95%CI=0.84-1.11). In the stratified analysis by ethnicity, no significant associations were found amongAsians and Caucasians. On stratification by tumor type, no significant associations were found for cancer andoral premalignant lesions. <br/><b>Conclusions</b>: The XRCC3 gene polymorphism was not found to be associated withthe risk of oral cancer. Considering the limited quality of the included case-control studies, more high qualitystudies with large sample size are needed to verify the above conclusion.