Background: The insulin-like growth factor (IGF) system comprises a group of proteins that play key rolesin regulating cell growth, differentiation, and apoptosis in a variety of cellular systems. The aim of this ...

Background: Tobacco is a leading preventable cause of deaths worldwide; the situation is particularlyserious in the developing countries. Tobacco use amongst the children and adolescents is already a pandemicand ...

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children andrepresents approximately 25% of cancer diagnoses among those younger than 15 years of age. Aim and Objectiv ...

Background: XELOX plus bevacizumab (XELOX-Bev) and FOLFIRI plus Bevacizumab (FOLFIRI - Bev)treatments are an effective strategies patients with metastatic colorectal cancer (mCRC).The aim of this studywas to compare ...

This study aimed to evaluate the prevalence of preoperative thrombocytosis and its prognostic significancein Thai patients with endometrial cancer. We retrospectively reviewed the medical records of 238 cases whohad undergone ...

Background: The aetiological relationship between human papillomavirus (HPV) infection and cervicalcancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican womenattending at ...

Background: The incidence rate of brain tumors has increased more than 40% in the past 20 years, especiallyin adults. We aimed to study the clinical and pathological findings of central nervous system (CNS) tumor ...

Background: Development of a nanosized polymeric delivery system for erlotinib was the main objectiveof this research. Materials and Methods: Poly caprolactone-polyethylene glycol-polycaprolactone ...

Background: Cancers impose an increasing burden on health of the populations and individuals, but little isknown about cancer patient satisfaction with care. The aim of this study was to assess the psychometric ...

Background: We defined melanoma distribution in a large series of Turkish patients and evaluated theprognostic parameters of melanomas. Materials and Methods: A total of 1574 patients’ data was ...

Opisthorchis viverrini (Ov) infection is the major etiological factor for cholangiocarcinoma (CCA), especiallyin northeast Thailand. We have previously reported significant involvement of PI3K/AKT/PTEN and Wnt/β-catenin ...

Background: Colon cancer is the second most common cancer in developed countries. Activated plateletsplay a key role in inflammation and atherothrombosis, with mean platelet volume (MPV) is an early markerof platelet ...

Easter Island is a small island of 180 km2, located 3,800 km from the Chilean coast and one of the mostisolated inhabited places in the world. Since the mid-twentieth century, it has been undergoing an epidemiologicaltransition ...

Stigmalactam, an aristolactam-type alkaloid extracted from Orophea enterocarpa, exerts cytotoxicityagainst several human and murine cancer cell lines, but the molecular mechanisms remain elusive. The aimsof this study were ...

Background: This study aimed to identify any association between the p73 gene G4C14-to-A4T14 polymorphismand risk of non-small cell lung cancer (NSCLC) in the south of China. Materials and Methods: We ...

Background: Molecular prognostic markers have been under investigation for the last decade and novalidated marker to date has been proven to be used in daily clinical practice for urinary bladder cancers. Theaim of ...

MicroRNA-27a is highly expressed in cancers and has been identified as an oncogenic microRNA. A geneticvariant in pre-miR-27a (rs895819) with a transition of A to G has been demonstrated to be associated with cancerrisk; ...

Apoptosis is a general phenomenon of all multicellular organisms and caspases form a group of importantproteins central to suicide of cells. Pathologies like cancer, Myocardial infarction, Stroke, Sepsis, Alzheimer’s,Psoriasis, ...

Background: MicroRNAs (miRNAs) are small non-coding RNA molecules found in multicellular eukaryoteswhich are implicated in development of cancer, including cutaneous squamous cell carcinoma (cSCC). Expressionis ...

Background: Previous epidemiologic studies on the association between energy intake and endometrial cancerrisk have only generated contradictory results. The role of energy intake in endometrial carcinogenesis ...