No Effect of Energy Intake Overall on Risk of Endometrial Cancers: a Meta-analysis

Abstract

<b>Background:</b> Previous epidemiologic studies on the association between energy intake and endometrial cancerrisk have only generated contradictory results. The role of energy intake in endometrial carcinogenesis thusremains unclear. To quantitatively assess the potential association between energy intake and endometrial cancer,a meta-analysis of case-control and cohort studies was here conducted. Materials and <br/><b>Methods</b>: Eligible studieswere retrieved via both computerized searches and review of references. Fixed-or random-effect models were usedto summarize the estimates of OR with 95%CIs. Stratified analyses on study design, region and macronutrients’calorie were performed. <br/><b>Results</b>: Sixteen studies met the inclusion criteria of the meta-analysis. No associationbetween total energy intake and endometrial cancer was observed in either overall group (OR=1.11, 95%CI0.92-1.30) or subgroups stratified by study design and region. In the specific macronutrients’ calorie analysis,higher fat energy intake was found to be associated with increased endometrial risk (OR=1.72, 95%CI 1.12-2.32) while energy from carbohydrate and protein was not related to endometrial cancer risk. <br/><b>Conclusions</b>: Ouranalysis did not support that total energy intake is related to endometrial cancer risk, in contrast to fat energy.