Parameters for Predicting Granulosa Cell Tumor of the Ovary: A Single Center Retrospective Comparative Study

Abstract

<b>Background:</b> To evaluate factors for predicting the granulosa cell tumor of the ovary (GCTO) pre-operatively.Materials and <br/><b>Methods</b>: This retrospective designed study was conducted on 34 women with GCTO as thestudy group and 76 women with benign ovarian cysts as the control group. Data were recorded from thehospital database and included age, body mass index (BMI), parity, serum estradiol (E2) levels, diameter of themass, ultrasonographic features, serum CA125 level, risk of malignancy index (RMI), duration of menopause,postoperative histopathology result, and the neutrophil/lymphocyte ratio (NLR). <br/><b>Results</b>: The demographicparameters showed no statistically significant difference between the groups. Preoperative diameter of the mass,CA125, duration of menopause, and neutrophil/lymphocyte ratio were significantly different between the groups.ROC curve analysis demonstrated that diameter of the mass, serum estradiol and Ca125 levels, RMI and NLRmay be discriminative factors in predicting GCTO preoperatively. <br/><b>Conclusions</b>: In conclusion, we think that acareful preoperative workshop including diameter of the mass, serum estradiol (E2) and Ca125 levels, RMI andNLR may predict GCTO and may prevent incomplete approaches.