Previous studies investigating the association between 5,10-methylenetetrahydrofolate reductase (MTHFR)gene polymorphisms and colon cancer risk have generated conflicting results. The aim of our meta-analysis wasto clarify ...

Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2(COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensiv ...

Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism andprostate cancer (PCa) risk has been reported in North American and Europe populations, though data fromAsian populations ...

Background: Breast cancer is the most common cancer in Iranian women and usually features delayedpresentation and late diagnosis. Interpretation of symptoms, as the most important step, has a significantimpact on ...

Objectives: Epidemiological studies have shown that molecular mechanisms underlying the development oflung cancers differ between smokers and unsmokers. Aberrant promoter methylation in some tumor suppressorgenes ...

Background: Previous studies accessing the association of CYP2C19 with outcomes of patients using tamoxifenfor breast cancer have yielded conflicting results. The aim of this meta-analysis is to obtain a more precise ...

A meta-analysis incorporating 34 case-control studies from 19 articles involving 12,197 cases and 13,488controls was conducted to assess the effects of three genetic variants of Toll-like receptor 9 (TLR9): rs187084,rs352140, ...

Background: Worldwide, over half a million women died of breast cancer in 2011 alone. Mammographyscreening is associated with a reduction of 20 to 35% in breast cancer mortality. The aim of this study was todetermine ...

The incidence rate of breast cancer in developed countries is almost three-fold higher than in developingcountries. Iran has had one of the lowest incidence rates for breast cancer in the world, but during the recentdecades ...

Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeuticstrategies and anticancer agents is an urgent priority. Plants have remained an important source in the searchfor novel ...

Background: Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression andtherapeutic resistance in many cancers. In the present study, we aimed to investigate the expression ...

Background: The National Central Cancer Registry of China (NCCR) affiliated to the Bureau of DiseaseControl, National Health and Family Planning Commission of China is responsible for cancer surveillancein the entire ...

Background: To compare the value of contrast-enhanced ultrasound (CEUS) qualitative and quantitativeanalysis in the identification of breast tumor lumps. Materials and Methods: Qualitative and ...

In many countries of the Association of Southeast Asian Nations (ASEAN), cancer is an increasing problemdue to ageing and a transition to Western lifestyles. Governments have been slow to react to the healthconsequences ...

Purpose: The aim of this study was to investigate the relationship between cell adhesion and anoikis evasionamong human osteosarcoma cells (MG-63), and to further study the molecular mechanisms. Materials andMethods: ...

This meta-analysis was performed to assess the implementation effects of clinical pathways in patients withgastrointestinal cancer. A comprehensive search was conducted in the Cochrane Library, PubMed, EMBASE,Web of Science ...

Background: Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide, with a highmortality. Most patients present with late stage disease, when the treatment options are limited to systemicchemotherapy. ...

Many studies have found links between diet and cancer. The summary estimates of the association betweendietary factors and cancer risk were investigated using previously reported studies of the Korean population.Gastric ...

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancerdevelopment and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes.The ...

Background: Blocking angiogenesis by targeting vascular endothelial growth factor (VEGF) signalingpathway to inhibit tumor growth has proven to be successful in treating a variety of different metastatic tumortypes, ...