To investigate the expression intensity and prognostic significance of TGF-β1 protein in non-small celllung cancer (NSCLC), immunohistochemistry was carried out in 194 cases of NSCLC and 24 cases of normallung tissues by ...

Previous studies investigating the association between 5,10-methylenetetrahydrofolate reductase (MTHFR)gene polymorphisms and colon cancer risk have generated conflicting results. The aim of our meta-analysis wasto clarify ...

Background: Cervical cancer is a major public health problem in Bangladesh. Persistence of high riskhuman papillomavirus (HRHPV) influences the progression of the disease, with an important role in followupfor ...

Performance status (PS) is a key factor in the selection of treatment in head and neck cancer patients (HNC).There is a probability in the development of an unfavorable PS with HNC advancing stages. This retrospectivestudy ...

Aims: To determine the clinical characteristics, pathological features, local and distant failure patterns inpatients with carcinoma of major salivary glands treated with surgery and postoperative radiotherapy (PORT).Materials ...

Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1)C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-basedchemotherapy ...

Gastric cancer continues to be a leading cause of cancer death. The majority of patients with gastricadenocarcinoma in China present with advanced disease. Ruling out unresectable cancers from an unnecessary‘‘open’’ ...

Background: Previous studies accessing the association of CYP2C19 with outcomes of patients using tamoxifenfor breast cancer have yielded conflicting results. The aim of this meta-analysis is to obtain a more precise ...

Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed basedsalvage chemotherapy for treatment of patients with metastatic colorectal cancer. Methods: Clinical ...

Purpose: To investigate the association of IL-17F rs763780T>C with cancer risk. Materials and C with cancer risk. Materials and Methods: Wesearched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National KnowledgeInfrastructure) ...

Background: Published data regarding associations between the -765G>C polymorphism in cyclooxygenase-2(COX-2) gene and digestive system cancer risk have been inconclusive. The aim of this study was to comprehensiv ...

Background: To assess the frequency and severity of gastrointestinal adverse effects in advanced colorectalcarcinoma patients treated with four different schedules of FOLFOX. Materials and Methods: ...

The incidence rate of breast cancer in developed countries is almost three-fold higher than in developingcountries. Iran has had one of the lowest incidence rates for breast cancer in the world, but during the recentdecades ...

Background: Organized cervical screening has decreased the incidence of cervical cancer. However, screeningstrategies vary in different countries. Objectives: We performed a systematic review to evaluate ...

Paclitaxel is one of the best anticancer agents that has been isolated from plants, but its major disadvantageis its dose-limiting toxicity. In this study, we obtained evidence that the active mutant IPP5 (8-60hIPP5m), ...

Genetic instability contributes to the development and progression of gastric cancer, one of the leadingcauses of cancer death worldwide. Microsatellite instability (MSI) has been hypothesized to be involved incarcinogenesis, ...

A meta-analysis incorporating 34 case-control studies from 19 articles involving 12,197 cases and 13,488controls was conducted to assess the effects of three genetic variants of Toll-like receptor 9 (TLR9): rs187084,rs352140, ...

Background: This study assessed human papillomavirus (HPV), cervical cancer, and HPV vaccine knowledgeand awareness among women in two sub-populations in Nepal - Khokana, a traditional Newari village in theLalitpur ...

Background: Blocking angiogenesis by targeting vascular endothelial growth factor (VEGF) signalingpathway to inhibit tumor growth has proven to be successful in treating a variety of different metastatic tumortypes, ...