Age and Survival of Cervical Cancer Patients with Bone Metastasis

Abstract

<b>Background:</b> To determine survival times of cervical cancer patients with bone metastasis related to theeffect of age at the time of cervical cancer diagnosis, we performed the retrospectively analytical study. <br/><b>Methods</b>:A total of 68 cervical cancer patients with bone metastasis were treated at a single hospital, during January1998 to December 2010. Fifty-two medical records were identified and collected, the remaining sixteen medicalrecords were not found. Main outcome measures were patient characteristics, clinical information, duration fromcervical cancer diagnosis to bone metastasis diagnosis, survival time after bone metastasis and overall survivaltime. <br/><b>Results</b>: Among fifty-two cervical cancer patients with bone metastasis, there were 13 patients who wereless than 45 years old, and 39 patients were 45 years old or more at the time of cervical cancer diagnosis. Theyounger group had less median overall survival than the older group, with a statistically significant difference(21 months, 95% CI 19.93-22.06; 34 months, 95% CI 23.27-44.72, p = 0.021). However, they were comparablein the duration from cervical cancer diagnosis to bone metastasis diagnosis and the survival time after bonemetastasis. <br/><b>Conclusion</b>: Young patients with bone metastasis aged less than 45 years old at the time of cervicalcancer diagnosis have a poorer prognosis than the elderly patients. Impact: To improve survival and quality oflife, more intensive and novel multimodal treatments at the time of cervical cancer diagnosis should be consideredin patients less than forty-five years, who can tolerate the side effects better.