Polymorphisms of TERT and CLPTM1L and the Risk of Hepatocellular Carcinoma in Chinese Males

Abstract

<b>Background:</b> Telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like(CLPTM1L) genes located on chromosome 5p15.33 are known to influence the susceptibility to various cancers.Here, we examined the association of TERT and CLPTM1L single nucleotide polymorphisms (SNPs) withhepatocellular carcinoma (HCC). Materials and <br/><b>Methods</b>: Genotyping of TERT SNP rs2736098 and CLPTM1LSNP rs401681 was performed using TaqMan allelic discrimination assays in a case-control study of 201 HCCcases and 210 controls in a Chinese male population. Odds ratios (ORs) and 95% confidence intervals (CIs) wereestimated using logistic regression analyses. <br/><b>Results</b>: Both the rs2736098 T allele of TERT and the rs401681 Tallele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605,95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individualscarrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420,95%CI= 2.319-8.425). The TERT rs2736098 T allele was also significantly associated with the level of the HCCclinical indicator alpha-fetoprotein (P=0.026). <br/><b>Conclusions</b>: Our results show that genetic variants of TERT andCLPTM1L may contribute to HCC susceptibility in Chinese males.