Lympho-Vascular Space Invasion Indicates Advanced Disease for Uterine Papillary Serous Tumors Arising from Polyps

Abstract

<b>Background:</b> Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was toevaluate uterine papillary serous tumors arising from polyps. Materials and <br/><b>Methods</b>: Clinicopathologicaldata of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department ofZekai Tahir Burak Women’s Health Education and Research Hospital were reviewed retrospectively. <br/><b>Results</b>:We analyzed patients according to FIGO 2009 staging system as stage 1A and higher than stage 1A (3 and 6,respectively). All the patients were postmenopausal. Mean CA-125, CA-19.9 and CA15.3 levels were elevatedin higher than stage 1A group. However we did not find a statistical difference between age, parity, polyp size,CA-125, CA-15.3, CA-19.9 and CEA levels. Lympho-vascular space invasion (LVSI) showed predictivity foradvanced disease (p=0.025). <br/><b>Conclusions</b>: The histopathologic nature of uterine serous carcinoma is a uniqueentity. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor.