Background: Chemokines and their receptors influence carcinogenesis and cysteine-cysteine chemokinereceptor 5 (CCR5) directs spread of cancer to other tissues. A 32 base pair deletion in the coding region of CCR5that ...

Breast cancer is a menacing cancer, primarily affecting women. Continuous research is going on for detectingbreast cancer in the early stage as the possibility of cure in early stages is bright. There are two main objectivesof ...

Treatment of early stage ovarian cancer remains controversial despite advances in chemotherapeutic options.Over the past 30 years, molecular and clinicopathologic studies accelerated and treatment of ovarian cancer ...

Background: To evaluate HPV testing by Hybrid Capture II (HCII) in conjunction with cytology in detectingthe residual/recurrence disease after treatment of high-grade cervical intraepithelial neoplasia (CIN II-III) ...

Background: Breast cancer is the most common cause of deaths of cancer in women. Nowadays, followingcompletion of imaging methods, mainly fine needle aspiration biopsy (FNAB) and core biopsy methods havebeen used ...

Background: Gastroenteropancreatic neuroendocrine tumors (GNs) are slow growing and although theirincidence has increased in recent years, they are relatively rarely seen. Somatostatin analogues are used inthe ...

Gastric cancer (GC) is one of the most common malignancies in the world. It is the first cause of cancerdeaths in both sexes In Iranian population. Circulating insulin-like growth factor-one (IGF-1) levels have beenassociated ...

Background: Public awareness/knowledge on oral and pharyngeal cancer (OPC), potentially malignantdisorders (PMODs) and their risk factors is crucial for prevention and early detection of OPC and PMODs.Yet, there are ...

Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates.Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In thisinvestigation, ...

Background: Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was toevaluate uterine papillary serous tumors arising from polyps. Materials and Methods: Clinicopathologicaldata ...

Colorectal cancer (CRC) is a worldwide health problem, being the third most commonly detected cancerin males and the second in females. Rising CRC incidence trends are mainly regarded as a part of the rapid‘Westernization’ ...

Background: Tight junctions (TJs) organise paracellular permeability and they have an important role inepithelial and endothelial cell polarity and permanence of barrier function. It has been demonstrated that ...

Background: Prognostic biomarkers in breast cancer are routinely investigated in the primary tumors to guidefurther management. However, it is proposed that the expression may change during the disease progression,and ...

The Bhopal gas tragedy involving methyl isocyanate (MIC) is one of the most horrific industrial accidentsin recent decades. We investigated the genotoxic effects of MIC in long-term survivors and their offspring bornafter ...

Common genetic variation Q192R in the paraoxonase 1 (PON1) gene has been considered to be implicated inthe development of many cancers. Nevertheless, results from the related studies were inconsistent. To elucidatethe ...

Background: Hepatitis B virus infection is one of the major world health problems. Epigallocatechin-3 gallateis the major component of the polyphenolic fraction of green tea and it has an anti-viral, anti-mutagenic, ...

Background: Globally, retinoblastoma is the most common primary intraocular malignancy occurring inchildren. This paper documents the recent incidence rates of retinoblastoma by age and sex groups from thePopulation ...

Objective: To investigate the diagnostic value of the R-way colposcopic evaluation system (R-way system)in cervical cancer screening. Materials and Methods: Between August 2013 and August 2014, a ...

Background: Levofloxacin is an effective medication for second line Helicobacter pylori (H. pylori) eradication.However, limited studies have approved its use as an effective antibiotic in first line therapy. ...

Background: The tumor-stroma ratio (TSR) represents the percentage of neoplastic cell components comparedto the combined area of neoplastic cells and the surrounding tumor-induced stroma. A low TSR (predominationof ...