Associations of CYP1A1, GSTM1 and GSTT1 Polymorphisms with Lung Cancer Susceptibility in a Northern Indian Population

Abstract

<b>Background:</b> Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphicgenes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which areinvolved in the bioactivation and detoxification of environmental toxins. This might be a factor in the variation inlung cancer incidence with ethnicity. Materials and <br/><b>Methods</b>: We conducted a case-control study of 218 northernIndian lung cancer patients along with 238 healthy controls, to assess any association between CYP1A1, GSTM1and GSTT1 polymorphisms, either separately or in combination, with the likelihood of development of Lungcancer in our population. <br/><b>Results</b>: We observed a significant difference in the GSTT1 null deletion frequency in thispopulation when compared with other populations (OR=1.87, 95%CI: 1.25-2.80–0.73, P=0.002). However, GSTM1null genotype was found associated with lung cancer in the non-smoking subgroup. (P=0.170). <br/><b>Conclusions</b>: Ourstudy showed the GSTT1 null polymorphism to be associated with smoking-induced lung cancer and the GSTM1null polymorphism to have a link with non-smoking related lung cancer.