Spleen tyrosine kinase (SYK) is a non-receptor type cytoplasmic protein and a known tumor suppressor genein breast cancer. Polymorphisms in SYK have been reported to be associated with cell invasion/cell moralityand an ...

Background: Mast cells can influence tumor progression via different pathways and increased mast celldensity has been demonstrated in oral squamous cell carcinoma (OSCC). It has been shown that the serumtryptase ...

Background: Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progressionof cancer. Many epidemiological studies have evaluated associations between the TNF-α 238 G/A polymorphismand ...

Background: Dilantin sodium (phenytoin) is an antiepileptic drug, which is routinely used to controlgeneralized tonic clonic seizure and partial seizure episodes. A few case reports of oral squamous cell carcinomasarising ...

Background: Faced with highly prevalent and recalcitrant cancer-related fatigue (CRF), together with theabsence of any official guidelines on management, numerous groups have been striving to seek and test ...

Background: Selecting chemotherapy regimens guided by chemosensitivity tests can provide individualizedtherapies for cancer patients. The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 ...

Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFRC677T and A1298C ...

Background: Bladder cancer is the second most incident malignancy among Lebanese men. The purposeof this study was to investigate potential risk factors associated with this observed high incidence. Methods: ...

Background: Under-ascertainment and over-ascertainment are common phenomena in surveillance andregistry systems of health-related events. Capture-recapture is one of the methods which is applied to determinethe ...

Background: Breast cancer is one of the most frequent diseases in women today. Little information exists onmodifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflamma ...

Backgrounds: Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute tointer-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidenceof adverse effects ...

Background: Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphicgenes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which areinvolved ...

The RAS family genes encode small GTP-binding cytoplasmic proteins. Activated KRAS engages multipleeffector pathways, notably the RAF-mitogen-activated protein kinase, phosphoinositide-3-kinase (PI3K) andRalGDS pathways. ...

Background: To explore mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS andTUBB3 genes in tumor tissue of postoperative patients with non-small cell lung cancer (NSCLC). Materialsand ...

Background: This study used National Health and Nutrition Examination Survey III to study the relationshipbetween blood lead concentration and all cause, all cancer and lung cancer mortality in adults. Patients ...

The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases area major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostatewhereas ...

Various studies examining the relationship between Ezrin overexpression and response to chemotherapy andclinical outcome in patients with osteosarcoma have yielded inconclusive results. We accordingly conducted ameta-analysis ...

Background: The aim of this study was to determine factors affecting sleep quality of 100 patients withadvanced stage lung cancer. Methods and Results: it was a descriptive study. A variety of assessment ...

Background: To investigate the internal validity of a food-frequency questionnaire (FFQ) developed for usein Chinese women and to compare habitual dietary intakes between population and hospital controls measuredby ...

Background: Visual inspection of cervix with acetic acid (VIA) is offered at 252 centers in 64 districts ofBangladesh. VIA+ve women are managed at colposcopy clinics of Bangabandhu Sheikh Mujib Medical University(BSMMU) ...