Relationship between Colonic Polyp Type and the Neutrophil/Lymphocyte Ratio as a Biomarker

Abstract

Aim: We designed this study to investigate the neutrophil lymphocyte ratio as a biomarker in distinguishingcolonic polyps which are neoplastic or non-neoplastic. Materials and <br/><b>Methods</b>: One hundred and twenty-fivepatients with colonic polyps were enrolled into the study. The following data were obtained from a computerizedpatient registry database: mean platelet volume (MPV), uric acid (UA), platelet count (PC), alkaline phosphatase(ALP), gamma-glutamyl transpeptidase (GGT) and the neutrophil to lymphocyte ratio (NLR). Exclusion criteriawere active infectious disease, hematological disorders, and malignancies. Colonic polyps divided into two groupsas neoplastic polyps (tubular adenoma, villous adenoma, tubulovillous adenoma) and non-neoplastic polyps(hyperplastic polyps, inflammatory pseudopolyps etc). The relationship between colonic polyp type and NLRwas evaluated with statistical analysis. <br/><b>Results</b>: There were 67 patients (53.6%) with neoplastic and 58 (46.4%)patients with non-neoplastic polyps. Mean NLRs of neoplastic and non-neoplastic groups were respectively3.32±2.54 and 2.98±3.16 (P<0.05). <br/><b>Conclusion</b>: Although sensitivity and specificity are not high, NLR may beused as a biomarker of neoplastic condition of colonic polyps.