Recurrence Season Impacts the Survival of Epithelial Ovarian Cancer Patients

Abstract

<b>Background:</b> Several studies indicated that the diagnosis season affects the prognosis of some cancers, suchas examples in the prostate, colon and breast This retrospective study aimed to investigate whether the diagnosisand recurrent season impacts the prognosis of epithelial ovarian cancer patients. <br/><b>Methods</b>: From January 2005to August 2010, 161 epithelial ovarian cancer patients were analyzed and followed up until August 2013. Kaplan-Meier survival curves and the log-rank test were used to make the survival analysis. Multivariate analysis wasconducted to identify independent prognostic factors. <br/><b>Results</b>: The prognostic factors of overall survival inepithelial ovarian cancer patients included age, clinical stage, pathological type, histological grade, residualdisease after primary surgery, recurrent season and adjuvant chemotherapy cycles. Moreover, clinical stage,histological grade, residual disease after primary surgery, recurrent season and adjuvant chemotherapy cyclesalso impacted the progression-free survival of epithelial ovarian cancer patients. The diagnosis season did nothave a significantly relationship with the survival of operable epithelial ovarian cancer patients. Median overallsurvival of patients with recurrent month from April to November was 47 months, which was longer (P < 0.001)than that of patients with recurrence month from December to March (19 months). Median progression-freesurvival of patients with recurrence month from April to November and December to March was 20 and 8months, respectively (P < 0.001). <br/><b>Conclusion</b>: The recurrence season impacts the survival of epithelial ovariancancer patients. However, the diagnosed season does not appear to exert a significant influence.