Background: To evaluate whether ABO-Rh blood groups have significance in the treatment response andprognosis in patients with non-metastatic breast cancer. Materials and Methods: We retrospectively ...

Background: In Iran, there are high rates of breast cancer. It is among the five most common cancers, thefirst among cancers diagnosed, and is the leading cause of cancer deaths among Iranian women. Objectives: ...

Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiplesmall molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism,was ...

Background: To determine the potential clinical utility of tumor markers CEA, TPA, and SCC-Ag for earlydetection of cervical precancerous lesions. Materials and Methods: A case-control study was carried ...

Background: To elucidate the role of rapamycin and PF4 on apoptosis regulation via Bax (pro-apoptosis),Bcl-2 (anti-apoptosis) and survivin activation on the growth in the 1-methyl-1-nitrosourea -induced invasivebreast ...

Background: This study investigated the utilization of both problem and emotion focused coping strategiesand their association with aspects of quality of life among Turkish women with ovarian cancer undergoingchemotherapy. ...

Background: Hepatocellular carcinoma (HCC) is a dismal tumor with a high incidence, prevalence and poorprognosis and survival. Management of HCC necessitates multidisciplinary clinics due to the wide heterogeneityin ...

Background: The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselectivecation channel that has been shown to promote tumor metastasis and progression. In this study, we determinedthe ...

Because of its importance in tumor invasion and metastasis, the epithelial-mesenchymal transition (EMT)has become a research focus in the field of cancer. Recently, evidence has been presented that FoxO4 might beinvolved ...

Background: This study used the receiver operating characteristic curve (ROC) to analyze Surveillance,Epidemiology and End Results (SEER) bronchioaveolar carcinoma data to identify predictive models and potentialdisparity ...

Background: Assessment of supportive needs is the requirement to plan any supportive care program forcancer patients. There is no evidence about supportive care needs of Iranian breast cancer patients. So, the aimsof ...

The tumour suppressor genes, p53 and pRb, are known to play important roles in neoplastic transformation.While molecular routes to the uncontrolled growth of hepatocytes, leading to primary liver cancer have generatedconsiderable ...

The X-ray repair cross-complementing group 1 protein (XRCC1) plays important roles in the DNA baseexcision repair pathway which may influence the development of lung cancer. This study aimed to evaluatethe potential ...

Background: Accurate assessment of disease progression requires proper understanding of natural diseaseprocess which is often hidden and unobservable. For this purpose, disease status should be clearly detected.But ...

Continued advances in the field of histo pathology (and cyto pathology) over the past two decades have resultedin dramatic changes in the manner in which these disciplines are now practiced. This is especially true in ...

Purpose: The aim of this study was to analyze any association between the metabolic syndrome (MetS) andrisk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materialsand ...

Background: Epidermal growth factor receptor (EGFR) mutations and echinoderm microtubuleassociated protein like 4-anaplastic lymphoma kinase (EML4-ALK) define specific molecular subsets of lungadenocarcinomas with ...

Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression andcell cycle progression. The active mutant IPP5 (8-60hIPP5m), the latest member of the inhibitory molecules forPP1, has ...

RASSF1A has been reported to be a candidate tumor suppressor in esophageal squamous cell carcinoma(ESCC). However, the association between RASSF1A promoter methylation and ESCC remains unclear. Eligiblestudies were identified ...

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recentevidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate theeffects of ...