Background: The aim of this study was to investigate the anti-cancer effects and mechanisms ofimmunochemotherapy of 5-fluorouracil (5-FU) and interleukin-2 (IL-2) on non-small cell lung cancer (NSCLC)A549 cells. ...

Protein phosphatase 1 (PP1) is a major serine/threonine phosphatase that controls gene expression andcell cycle progression. The active mutant IPP5 (8-60hIPP5m), the latest member of the inhibitory molecules forPP1, has ...

Background: To determine the potential clinical utility of tumor markers CEA, TPA, and SCC-Ag for earlydetection of cervical precancerous lesions. Materials and Methods: A case-control study was carried ...

Background: Accurate assessment of disease progression requires proper understanding of natural diseaseprocess which is often hidden and unobservable. For this purpose, disease status should be clearly detected.But ...

RASSF1A has been reported to be a candidate tumor suppressor in esophageal squamous cell carcinoma(ESCC). However, the association between RASSF1A promoter methylation and ESCC remains unclear. Eligiblestudies were identified ...

The X-ray repair cross-complementing group 1 protein (XRCC1) plays important roles in the DNA baseexcision repair pathway which may influence the development of lung cancer. This study aimed to evaluatethe potential ...

Background: Cytogenetic abnormalities have important implications in diagnosis and prognosis of acuteleukemia and are now considered an important part of the diagnostic workup at presentation. Karyotype, ifknown at ...

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recentevidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate theeffects of ...

Background: This study investigated the utilization of both problem and emotion focused coping strategiesand their association with aspects of quality of life among Turkish women with ovarian cancer undergoingchemotherapy. ...

Curcumin, a polyphenol compound derived from the rhizome of the plant Curcuma longa L. has been verifiedas an anticancer compound against several types of cancer. However, understanding of the molecular mechanismsby which ...

Emerging evidence has shown associations of microRNA-205 (miR-205) with crucial cell processes such as theepithelial-mesenchymal transition (EMT) and aberrant expression with tumorigenesis in many types of humanmalignancy. ...

Background: A cancer registry program has been established in East Azerbaijan and this has emphasizedthe importance of cancers of gastrointestinal tract in this region. The aim of the present pathology-based ...

Background: Most patients with endometrial cancer have stage I disease. Adjuvant therapy in stage IB(formerly IC) endometrial cancer is controversial, treatment options including observation or brachytherapy/radiotherapy ...

Background: In chronic hepatitis B (CHB), the presence of hepatic steatosis (HS) seems to be associated withknown host and viral factors which may influence the long-term prognosis of chronic hepatitis B (CHB), ...

Continued advances in the field of histo pathology (and cyto pathology) over the past two decades have resultedin dramatic changes in the manner in which these disciplines are now practiced. This is especially true in ...

Background: Infection with certain human papillomavirus (HPV) genotypes is the most important riskfactor related with cervical cancer. The objective of the present study was to investigate the prevalence of HPVinfection, ...

Background: Previous studies have showed that argonaute 2 is a potential factor related to genesis of severalcancers, however, there have been no reports concerning gliomas. Methods: Paraffin specimens ...

Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remaincontroversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Materialand ...

Because of its importance in tumor invasion and metastasis, the epithelial-mesenchymal transition (EMT)has become a research focus in the field of cancer. Recently, evidence has been presented that FoxO4 might beinvolved ...

Purpose: The aim of this study was to analyze any association between the metabolic syndrome (MetS) andrisk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materialsand ...