Background: The serum carcinoembryonic antigen (CEA) level can reflect tumor growth, recurrence andmetastasis. It has been reported that epidermal growth factor receptor (EGFR) mutations in exons 19 and 21mayhave ...

Aim: To investigate the effects of tetramethypyrazine (TMP) on proliferation and apoptosis of the humangastric carcinoma cell line 7901 and its possible mechanism of action. Methods: The viability of TMP-treated7901 ...

Background: Published studies on the association between the Ras Association Domain Family 1 isoform A(RASSF1A) Ala133Ser polymorphism and cancer susceptibility have yielded conflicting results. Thus, a metaanalysiswas ...

Breast cancer is the most common in women worldwide, with some 5-10% of all cases due to inheritedmutations of BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of alcohol are possible causesand over-expression of ...

Background: Cancer is becoming the most important public health burden around the globe. As per theGLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths were estimatedto have occurred ...

Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 12-15 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes toformation ...

Background: In recent years, numerous studies have been performed to investigate the CCND1 G870Agene polymorphism impact on brain tumors susceptibility. Unfortunately, the results of previous studies wereinconsistent. ...

Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients withadvanced non-small cell lung cancer (NSCLC). Materials and Methods: A total of 72 patients were ...

Background: Osteosarcomas are the most common solid malignancies of bone. In the last two decadesthere have been no concrete developments in their systemic treatment. In this trial we aimed to present ourosteosarcoma ...

Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. It hasbeen hypothesized that Oct4 positive radioresistant stem cells may be responsible for tumor recurrence. Hence,we ...

Background: Interleukin-33 (IL-33) has recently been implicated in tumor development. Methods: Datawas obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of Science, CNKI and Wanfangdatabases. ...

Background: In Mexico, breast cancer (BCa) is the leading type of cancer in women. Cytochrome P450(CYP450) is a superfamily of major oxidative enzymes that metabolize carcinogens and many antineoplasticdrugs. In ...

Background: To determine the frequency of dysplastic lesions in the endocervical curettage (ECC) specimensof women with ASC-US and LSIL Pap and to evaluate the possible factors associated with high grade dysplasia ...

To assess inhibition mechanisms of a Phellinus igniarius (PI) extract on cancer, C57BL/6 mice were orallytreated with PI extractive after or before implanting H22 (hepatocellular carcinoma ) or B16 (melanoma) cells.Mice ...

Background: Prostate cancer is rapidly increasing in Korea and professional societies have requested addingprostate specific antigen (PSA) testing to the National Cancer Screening Program (NCSP), but this started ...

Aims: To identify the psychosocial adjustment of Turkish patients with breast cancer and the effects ofperceived social support on their adjustment. Materials and Methods: The sample comprised 100 volunteeringpatients ...

Background: Our aim was to conduct a meta-analysis to compare the efficacy and safety of pemetrexedand docetaxel for non-small cell lung cancer (NSCLC). Materials and Methods: We systematically searchedthe ...

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers in men and the third mostcommon cancer in woman in Thailand. This retrospective study was designed to assess the prevalence, clinicalman ...

Background: Gallbladder carcinoma (GBC) is the most common carcinoma of the biliary system. Among itsresearch models, orthotopic xenograft models, important research tools, have been rarely reported in the ...

Background: Aberrant expression of the microRNA-29 family is associated with tumorigenesis and cancerprogression. As transport carriers, tumor-derived exosomes are released into the extracellular space and ...