Background: Studies investigating the association of 2R/3R polymorphism in the thymidylate synthase5’-untranslated enhanced region (TSER) and colorectal cancer (CRC) risk have reported conflicting results. Thus,a ...

Objective: This study is conducted to evaluate the effects of anti-HER-2×anti-CD3 bi-specific antibodies(BsAb)on HER-2/neuover-expressing human colorectal carcinoma cells. Methods: Growth was assessed ...

Background: There is a long standing interest in the identification of medicinal plants and derived naturalproducts for developing cancer therapeutics. Here we investigated the antiproliferative properties of ...

Aim: To study the causes and significance of both microscopic and macroscopic haematuria in adult patientsand assess possible relevance to early detection of urological cancers. Methods: 417 patients presenting ...

Objectives: An attempt was made to understand the nicotine dependence of smokers selected for an ongoingsmoking cessation intervention programme in rural Kerala, India. Methods: Data were collected ...

Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophagealsquamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22and ...

Biological response modifiers (BRMs) can alter interactions between the immune system and cancer cells toboost, direct, or restore the body’s ability to fight disease. Mice with ethylnitrosourea- (ENU) induced leukemiawere ...

Introduction: Although bleomycin/etoposide/cisplatinum (BEP) chemotherapy is established as the standardtreatment for germ cell tumours, it requires significant experience in administration and toxicity ...

Aims: A case-control study of 300 gastric cancer patients and 300 controls was conducted to investigatewhether the polymorphisms rs2294008 in PSCA and rs2070803 in MUC1 might be associated with risk of gastriccancer in a ...

Oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage in avariety of liver disorders. Hence there is a great demand for the development of agents with potent antioxidanteffect. ...

Annona muricata L (Annonaceae), commonly known as soursop has a long, rich history in herbal medicinewith a lengthy recorded indigenous use. It had also been found to be a promising new anti-tumor agent innumerous in vitro ...

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breastcancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, ...

Background: Hepatocellular carcinoma (HCC), the main malignant tumor of the liver, is very commonand highly lethal. The aim of this study was to determine its clinicopathologic characteristics and risk factorsin ...

Background: There are limited data evaluating the cost-effectiveness of gastric cancer screening usingendoscopy or upper gastrointestinal x-ray in the general population. Objective: To evaluate the ...

Validation of a food frequency questionnaire (FFQ) utilising a short-term measurement method ischallenging when the reference method does not accurately reflect the usual food intake. In addition, foodgroup intake that is ...

Purpose: Pancreatic carcinoma is one of the most malignant tumors of the alimentary system, with relativelyhigh incidence rates. The purpose of this study was to assess the efficacy and safety of two regimens for ...

Despite clinical advances in anticancer therapy, there is still a need for novel anticancer metabolites, withhigher efficacy and lesser side effects. Oroxylum indicum (L.) Vent. is a small tree of the Bignoniaceae familywhich ...

Aim: Gastric cancer is the third most frequent cause of cancer mortality worldwide. In Iran, it is one of theleading causes at the national level. Localized at chromosome 8q22, the human MTDH gene has been reportedto be ...

Background: Raw betel nut (RBN) chewing is an important contributing factor for esophageal squamous cellcarcinoma (ESCC), although associated genomic changes remain unclear. One difficulty in assessing the effectsof ...

Aims: We conducted a case-control study in a Chinese population to clarify the association betweenpolymorphisms in ERCC1 and XPD and susceptibility and survival of glioma. Methods: A total of 393 cases and410 ...