The association between selected RANKL gene polymorphisms and chronic/aggressive periodontitis in Iranian subjects

Abstract

The primary aim of this study was to investigate the status of RANKL6-7 gene polymorphism in patients with chronic (mild, moderate, severe) and aggressive periodontitis as well as healthy controls. We examined<br />80 patients for the RANKL6-7 polymorphisms (rs1054016 and rs9567000). Polymorphism was determined<br />by polymerase chain reaction (PCR) followed by direct sequencing. No statistically significant association<br />was found between the polymorphism in the RANKL 7 gene and periodontal disease (P<0.55).<br />There was also no polymorphic allele observed in RANKL 6 gene of the study population. We found no<br />association between the studied RANKL polymorphisms and chronic/aggressive periodontitis.