Evaluation of Antifungal Effect of Silver Nanoparticles Against Microsporum canis, Trichophyton mentagrophytes and Microsporum gypseum

Abstract

Background : Dermatophytosis is the common cutaneous infections in humans and animals, which is caused by the keratinophylic fungus called dermatophytes. In recent years , drug-resistance in pathogenic fungi, including dermatophytes to the current antifungal have been increased . The aim of this study was to evaluate the antifungal efficacy of AgNPs against Microsporum canis, Trichophyton mentagrophytes, and Microsporum gypseum. Materials and Methods: The antifungal susceptibility of nano-silver particles (AgNPs) compared with Griseofulvin (GR). Its efficacy was investigated against three strains of dermatophytes by both agar dilution and broth microdilution test (BMD). Results : The average minimum inhibitory concentration (MIC) of Ag-NPs on M. canis, T. mentagrophytes and M. gypseum were 200, 180, and 170 μg/ml , respectively. Whereas these strains showed MIC of 25, 100 and 50 μg/ml for Griseofulvin (GR). Conclusions: Our finding indicated that the AgNPs was less active than Griseofulvin (GR) but it had anti-dermatophytic effect.