Effect of the Synthesis Parameters on the Properties of Biphasic Ca(OH) -HA Nanopowders for Tissue Engineering Applications

Abstract

Nanocrystalline hydroxyapatite was precipitated from calcium hydroxide and phosphoric acid. Effects of precipitation temperature and different calcium to phosphate ratios (Ca/P) on the obtained powders were investigated. Characteriza-tion of the powders was performed using XRD and FTIR spectra, scanning electron microscopy, and transmission electron microscopy. Increase in precipitation temperature increases the size and crystallinity of obtained crystals. Samples with Ca/P ratios more than stoichiometric ratio (1.67) had calcium hydroxide in their structures which is suitable for dental applications. Lower precipitation temperatures lead to lower crystallinity which is ideal for dental applications due to an increase in calcium hydroxide release.