Wound Healing and Toxicity Evaluation of Aloe vera Cream on Outpatients with Second Degree Burns

Abstract

<em> Aloe vera </em>is a tropical plant belonging to the Liliaceae family. It has beneficialeffects in variety of diseases. The aim of this study was to formulate a topical cream from <em>A. vera</em> with wound burn healing effect and to perform its clinical trial. A total of 30 patients (20 males and 10 females in the age range of 20-50 years) with second degree burn wounds on their both hands were selected for the study. The subjects used <em>A. vera</em> topical formulation or silver sulfadiazine 1% cream on each hand as the test and control, symmetrically. The rate of healing was measured and compared on 0 to 18 days after treatment. Results indicated that average percent of healing with <em>A. vera</em> on day 10 was 90.6% compared with silver sulfadiazine which was only 29.8% (<em>p</em>A. vera on burn wounds without any adverse dermal toxic effects is very promisingand it may be employed in management of burn wound, routinely.