Synthesis of Hydroxyapatite Nanostructure by Hydrothermal Condition for Biomedical Application

Abstract

In this investigation, hydroxyapatite (HAp) nanostructure with uniform morphologies, controllable size, nano-dispersion and narrow-size distribution in diameter has been synthesized successfully by low-temperature hydrothermal process, and the as-synthesized powders were characterized by energy-dispersive X-ray spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy (HRTEM), Fourier transform infrared, and induced couple plasma (ICP). In the present work, a novel technique of sono-chemical of CaHPO₄.2H₂O/NaOH/distilled water with cetyltrimethylammonium bromide ((CH₃(CH₂)₁₅N⁺(CH₃)₃Br^-) designated as CTAB) under hydrothermal condition to synthesize HAp nanostructure was described. Furthermore, the usage of a high basic condition a water environment is the two crucial keys in ensuring the formation of HAp the hydrothermal/sonochemical processes. However, the crystallite size and crystallinity degree of the HAp increased with the addition of annealing temperature. Indeed, the present work will introduce new method in synthesis of HAs for scientific and medical engineering.