Comparison of the Effect of Hydrophilicity on Biocompatibility and Platelet Adhesion of Two Different Kinds of Biomaterials

Abstract

Determination of blood compatibility is an important problem in blood contacting devices. In this study, two classes of materials including polyurethane (based on polyethylene glycol and poly tetrametylene oxide) and polyvinyl alcohol samples, with different hydrophilicity properties were synthesized and their physico-chemical properties were compared. Water uptake ratio, FTIR spectroscopy, and contact angle measurement were conducted. <em>In vitro</em> biocompatibility experiments were undertaken using L-929 fibroblast cell lines which demonstrated desired cell viability for all samples after 7 days. The adhesion of platelets from human plasma was studied by optical microscopy. Blood coagulation time were also determined which revealed polyurethane based poly tetramethylene oxide has better interaction by blood elements among all samples.