The SOCS-1 -1478CA/del Polymorphism is not Associated with Colorectal Cancer or Age at Onset in Turkish Subjects

Abstract

<b>Background:</b> Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signalingpathways and its abnormal expression has been identified in several human malignancies, suggesting potentialroles in carcinogenesis. The aim of this study was to investigate any association between the functional SOCS-1 -1478CA>del polymorphism and colorectal cancer (CC) as well as age at onset in a Turkish clinical sample.Materials and <br/><b>Methods</b>: A total of 122 subjects were enrolled in this case-control study (70 CC cases and 52controls). The SOCS-1 -1478CA>del polymorphism was genotyped using a polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP) method. <br/><b>Results</b>: The odds ratio of the del allele for CC relativeto the CA allele was not significantly different between the groups (OR=0.71, 95% CI=0.41–1.22, p=0.27). Thisresult did not change after adjustment for age and sex on multivariable regression analysis (OR=0.84, 95%CI=0.59–1.34, p=0.53). When the SOCS-1 -1478CA>del polymorphism was analyzed among CC patients inrelation to the age at disease onset, we found no significant differences between subjects with the del/del, CA/del,and CA/CA genotypes. <br/><b>Conclusions</b>: The results of our study did not point towards a major role of the SOCS-1-1478CA>del polymorphism in the pathogenesis of CC in Turkish subjects.