To analyze the effects of a new unknown peptide DEF on the growth of tumor cells, a fused polypeptideTAT-DV1-DEF was designed and synthesized. The lung adenocarcinoma cell line GLC-82 treated with TATDV1-DEF was analyzed ...

Background: Cervical cancer continues to be a major problem in Bangladesh with approximately 18,000 newcases annually of which over 10,000 women die from it. Visual inspection of the cervix after 3-5% acetic acid(VIA) ...

Human epidermal growth factor receptor (HER) status is an important prognostic factor in breast cancer.There is no globally accepted method for determining its status, and which method is most precise is stilla matter of ...

Background: Cancer incidence rates are increasing particularly in developing countries. It is crucial for policymakers to know basic cancer epidemiology in each region to design comprehensive prevention plans. There ...

Background: Gambogenic acid is a major active compound of gamboge which exudes from the Garciniahanburyi tree. Gambogenic acid anti-cancer activity in vitro has been reported in several studies, including anA549 ...

DNA repair capacity is crucial in maintaining cellular functions and homeostasis. However, it can be alteredbased on DNA sequence variations in DNA repair genes and this may lead to the development of many diseasesincluding ...

Aims: To evaluate breast self examination (BSE) practice and the effect of a training program conducted byhealthcare professionals on BSE. Materials and Methods: Women were randomized into control and test ...

Background: In a prospective cohort study of antiemetic therapy conducted in Malaysia, a total of 94patients received low emetogenic chemotherapy (LEC) with or without granisetron injections as the primaryprophylaxis ...

Malignant bowel obstruction (MBO), an occasional complication in patients with advanced urological cancer,causes gastrointestinal symptoms such as nausea and vomiting leading to suffering which severely impairs qualityof ...

Objective: Increasing scientific evidence suggests that common variants in the PALB2 gene may confersusceptibility to breast cancer, but many studies have yielded inconclusive results. This meta-analysis aimed ...

Background: Suppressor of cytokine signaling (SOCS)-1 acts as a key regulator of many cytokine signalingpathways and its abnormal expression has been identified in several human malignancies, suggesting potentialroles ...

Aim: To investigate the effects of diallyl trisulfide (DT) on apoptosis of cisplatin (DDP)-resistant humanepithelial ovarian cancer SKOV-3 cells (SKOV-3/DDP), and the role of p53 upregulated modulator of apoptosis(PUMA). ...

Aim: To identify new biomarkers for NPC diagnosis with an anti-EBV Western blot test kit. Methods:Serum samples from 64 NPC patients and healthy subjects with four specific VCA-IgA/EA-IgA profiles weretested ...

The main aim of this study was to investigate the roles of GST-π and polβ genes in the chemoresistance ofesophageal carcinoma cells. Eukaryotic expression vectors containing each gene were constructed and transfectedinto ...

Background: Only few epidemiological data on primary central nervous system (CNS) tumors in Shanghaihave been reported. Methods: All cases of primary CNS tumors that were registered at Center for ...

Background: Human papilloma virus infection is associated with genesis and malignant potential ofcervical cancer. E6 and E7 oncogens are known to bind to p53 and retinoblastoma gene products, abrogatingtheir functions ...

Background: Globally, there have been important changes in trends amongst gender, histology and smokingpatterns of lung cancer cases. Materials and Methods: This retrospective study was conducted on 466 ...

The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is recommended in hematologicalmalignancy patients and before hematopoietic stem cell transplantation (Guidelines for the prevention andmanagement of ...

Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poorsurvival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We ...

Background and Objective: Rectal washout with saline solution may theoretically prevent anastomoticrecurrence in patients with resectable rectal cancer, although exact clinical effects have not yet been determined. ...