Human Papillomavirus (HPV) Infection in Women Participating in Cervical Cancer Screening from 2006 to 2010 in Shenzhen City, South China

Abstract

Purpose: Human papillomavirus (HPV) infection plays an important role in the development of cervicalcancer, but the prevalence of HPV infection in women of Shenzhen city remains unclear. The present study wasperformed to describe the change of cervical HPV infection in females who participated in voluntary cervicalcancer screening from 2006 to 2010 in Shenzhen city, China. <br/><b>Methods</b>: A total of 4, 413 women were recruited.HPV infections were genotyped by polymerase chain reaction (PCR) and reversed dot blot hybridization inShenzhen Maternity and Child Health Hospital. <br/><b>Results</b>: The prevalence of HPV infection was 13.8%. The fivemost commonly found HPV types were HPV16 (3.47%), HPV58 (1.68%), HPV33 (1.38%), HPV43 (1.36%) andHPV18 (1.27%). The secular trends of major HPV type-specific were diverse. Among of them, the prevalence ofHPV18 increased sharply while others increased slowly or even decreased in the period. The change of total HPV,single HPV and multiple HPV infection were similar during the five years. <br/><b>Conclusions</b>: Our findings suggestedthat HPV infection is common with HPV16 and HPV 58 as the primary subtypes in women in Shenzhen city.The prevalence of HPV 18 infection is increasing faster than any others, which will lead it to be one of the mainsubtypes in this city in the future.