Lack of any Association between Insertion/Deletion (I/D) Polymorphisms in the Angiotensin-converting Enzyme Gene and Digestive System Cancer Risk: a Meta-analysis

Abstract

<br/><b>Objective</b>: To investigate the association between the gene polymorphisms of angiotensin-converting enzyme(ACE) and digestive system cancer risk. <br/><b>Method</b>: A search was performed in Pubmed, Medline, ISI Web ofScience and Chinese Biomedical (CBM) databases, covering all studies until Sep 1st, 2013. Statistical analysiswas performed by using Revman5.2 and STATA 12.0. <br/><b>Results</b>: A total of 15 case-control studies comprising 2,390digestive system cancer patients and 9,706 controls were identified. No significant association was found betweenthe I/D polymorphism and digestive cancer risk (OR =0.93, 95%CI = (0.75, 1.16), P =0.53 for DD+DI vs. II). Inthe subgroup analysis by ethnicity and cancer type, no significant associations were found for the comparisonof DD+DI vs. II. Results from other comparative genetic models also indicated a lack of associations betweenthis polymorphism and digestive system cancer risks. <br/><b>Conclusions</b>: This meta-analysis suggested that the ACED/I polymorphism might not contribute to the risk of digestive system cancer.