How to Establish Acute Myeloid Leukemia Xenograft Models Using Immunodeficient Mice

Abstract

The discovery of the immunodeficient mice has provided a tool for establishing animal models as hosts for invivo analysis of AML. Various model systems have been established in the last few decades, and it is essential thatmurine AML models are developed to exploit more specific, targeted therapeutics. In this review, we concentrate onthe models of AML and discuss the development of immunodeficiency models for understanding of leukemogenesis,describe those now available and their values and document the methods used for establishing and identifyingAML mice models, as well as factors influencing engraftment of human AML in immunodeficient mice. Thus,the function of this article is to provide clinicians and experimentalists with a chronological, comprehensiveappraisal of all AML model systems.