SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Abstract

We conducted a case-control study to determine the association between several potential SNPs of excisionrepair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphismsin combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newlydiagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>Tand rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detectorsystem. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CCwas associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findingssuggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, butthe effect needs to be further validated by larger sample size studies.