Background: Northern Iran counts as one of the highest prevalence regions for esophageal cancer (EC)worldwide. This study was designed to assess the epidemiologic aspects of EC in north central and northwestIran ...

Background: Previous studies have observed an association between ABO blood group and risk for certaingastrointestinal malignancies, including pancreatic and gastric cancer. However, it is unclear whether thereis ...

Background: No factor has thus far been identified to predict the efficacy of bevacizumab therapy forcolorectal cancer. We here therefore studied PTEN, VEGF, HER2 and p53 by immunohistochemistry as possibleprognostic ...

Survivin, a new member of the inhibitor of apoptosis protein (IAP) family, both inhibits apoptosis andregulates the cell cycle. It is overexpressed in breast tumor tissues. In this study, we designed two survivinspecific ...

Introduction: Up to present, EGF 61*A/G, TGF-β1 -509*T/C and TNF-α-308*A/G gene polymorphisms havebeen analysed in other cancer entities than hepatocellular carcinoma (HCC). We here investigated the frequencyof ...

Background: To determine the frequency of HER-2 overexpression in colorectal cancer (CRC) patients,and to explore the relationship between clinicopathological prognostic factors and their effects on survival,based ...

Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide associationstudy (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotidepolymorphisms ...

Interleukin-4 receptor (IL-4R) gene single nucleotide polymorphisms (SNPs) are implicated in cancerdevelopment. However, results from the published reports have remained inconclusive. The objective of thisstudy was to ...

Objective: To investigate the effects of gambogic acid (GA) on the growth of human malignant glioma cells.Methods: U251MG and U87MG human glioma cell lines were treated with GA and growth and ...

Introduction: Epidemiological studies suggest a protective role for β-carotene with several malignancies. Esophageal adenocarcinoma frequently arises from Barrett’s esophagus (BE). We postulated that β-carotene ...

Background: Clinical trials on cancer subjects have one of the highest dropout rates. Barriers to recruitmentrange from patient-related, through institutional-related to staff-related factors. This paper highlights ...

This study was designed to identify beliefs about physical activity in cancer patients. Semi- structured interviews were conducted with 20 patients under treatment, who were invited to identify perceived barriers for not ...

Bracken fern [Pteridium aquilinem (L.) kuhn (Dennstaedtiaceae)] is one of the most common species on the planet. It has been consumed by humans and animals for centuries. Use by some human groups is because theybelieve ...

This cross-sectional and descriptive study was aimed to evaluate women breast self-examination (BSE)practice and effects of a planned educational programme for breast cancer and BSE. The samples of the studyconsisted 266 ...

Hepatocellular carcinoma (HCC), the sixth most prevalent cancer worldwide, continues to have high prevalence in many countries of Asia. The main challenge is the high prevalence of chronic hepatitis and aflatoxin, for ...

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal,either ...

Cervical cancer is the second most common cancer in females in the World with around 500,000 new casesoccurring annually, but the first in the developing countries with a high mortality if not diagnosed early.Papanicolau ...

Background: Multiple myeloma is the most common malignant plasma cell dyscrasia and ranks secondamong primary haematological malignancies. This study describes the epidemiologic, clinical and pathologicprofile of ...

Objective: To investigate the relationship between plasma EBV-DNA concentration and clinicopathologicfeatures of Hodgkin’s lymphoma cases. Methods: At first, the positive rate of plasma EBV-DNA was ...

Background: The mucin components of the gastric gel layer function as a protective and lubricatingfactor against luminal acid and proteolytic enzymes. Alteration of mucin expression in gastric preneoplasticand ...