Homogeneity in Case/Control Numbers and North Indian Caste Criteria in Cervical Cancer/Female Urology Genetic- Studies at a Premier Medical Research Institute in Lucknow, India

Abstract

Cervical cancer has emerged as a major public health problem in Lucknow and New York in the 21st century.Cancer genetic studies are essential to identify/stratify disease-susceptible individuals in a population-basedcohort. Sample size homogeneity and North Indian caste in female urology genetic-studies are significant issuesin meaningful interpretation of data. A review of scientific literature using Pubmed database was conducted,including an assessment of cervical cancer genetic studies conducted as part of the author’s doctoral dissertationat a premier Lucknow-based medical research Institute. Sample size numbers and caste criteria in the NorthIndian cohort (N≤400 subjects) were evaluated with homogeneity in the sample cohort data set(s). Subgroupcaste-stratification of North Indian cohort is equally essential, for instance, Brahmin (e.g. Pandey), Vaishya(e.g. Mittal), Rajput (e.g. Singh) and Kshudra (e.g. Yadav) during the conception and design of genetics-basedstudies. Sample size homogeneity in histopathologically confirmed case and control numbers and caste-basedstratification in a North Indian cohort is essential in single nucleotide polymorphism (SNP) studies in cervicalcancer susceptible populations to draw more definitive conclusions.