Our aim was to explore anti-cell proliferative and anti-angiogenic potential of andrographolide by analyzingthe expression pattern of cell proliferative (PCNA, Cyclin D1) and angiogenic (VEGF) markers during 7,12-dimethy ...

Pharmacological and preventive properties of Petroselinum sativum seed extracts are well known, but theanticancer activity of alcoholic extracts and oil of Petroselinum sativum seeds on human breast cancer cellshave not ...

Background: Phytochemical compounds are emerging as a new generation of anticancer agents with limitedtoxicity in cancer patients. The purpose of this study was to investigate the potential effcts of thymoquinone,caffeic ...

ANXA2, a member of the annexin family, is overexpressed and plays important roles in tumor development.However, the significance of ANXA2 expression in gastric carcinoma has not been clarified.To elucidate its rolesin ...

Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repaircomplementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of thisstudy ...

Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedlystressed in different parts of the world. A case control study aimed to evaluate the relationship between thetwo was ...

Background: Cervical cancer is the second commonest female cancer worldwide. The 50-55 cases of cervicalcancer are reported annually in the UAE. There is a scarcity of data from Middle Eastern region regardingknowledge ...

Background: Apoptosis may be induced after Bcl-2 expression is inhibited in proliferative cancer cells. Thisstudy focused on the effect of autophagy activation by ABT737 on anti-tumor effects of epirubicin. ...

Background: The aim of the study was to determine breast cancer risk and early diagnosis applications inwomen aged ≥50. Materials and Methods: This cross-sectional, descriptive field study focused on a ...

Research indicates that a small population of cancer cells is highly tumorigenic, endowed with the capacityfor self-renewal, and has the ability to differentiate into cells that constitute the bulk of tumors. These cells ...

In December 2011, the Cancer Research Centre of the Cancer Institute of Iran sponsored a 3-day workshopon “Cancer Registration Principle and Challenges in Iran”, which convened cancer registry experts. Theobjectives of the ...

Curcumin and curcumin containing polyherbal preparations have demonstrated anti-microbial and antiviralproperties in pre-clinical studies. Till date no therapeutic intervention has been proved to be effective andsafe in ...

Objectives: To compare the clinicalpathological features and prognosis between premenopausal breastcancer patients aged of Methods: The clinical data and survival status of ...

Objective: To investigate the clinical effects of whole brain radiotherapy concomitant with targeted therapyfor brain metastasis in non-small cell lung cancer (NSCLC) patients with chemotherapy failure. Materials ...

Objective: Major histocompatibility complex class I chain-related A (MICA) is a stress-inducible glycoproteinthat can be shed as a soluble protein. This study was conducted to determine the expression of MICA ...

Background: To evaluate the clinicopathologic and demographic characteristics of triple-negative breastcancer (TNBC) patients and to determine differences from non-triple-negative cases. Materials and Methods: ...

Background: The gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common typeof neuroendocrine neoplasm. We summarized data in our centre to investigate the clinicopathological features,diagnostic ...

Incidence/mortality of liver cancer follow logistic curves because there is a limit reflecting the prevalence ofhepatitis virus carriers in the cohort. The author fitted logistic curves to incidence/mortality data covering ...

Background: Cancer is a complex disease caused by multiple factors, both genetic and environmental. It is amajor health concern worldwide, in the Middle East and in Jordan specifically and the fourth most common ...

In order to enhance the bioavailability of curcumin its conjugates with piperic acid and glycine weresynthesized by esterifying the 4 and 4’ phenolic hydroxyls, the sites of metabolic conjugation. Antiproliferativeand ...