Clinical Features and Survival Analysis of Very Young (Age<35) Breast Cancer Patients

Abstract

<br/><b>Objectives</b>: To compare the clinicalpathological features and prognosis between premenopausal breastcancer patients aged of <35 and ≥35 years old. <br/><b>Methods</b>: The clinical data and survival status of 1498 casespremenopausal operable breast cancer treated in our hospital from 2002.1 to 2004. 12 were collected, 118 caseswere aged <35. They were divided into 4 groups: Luminal A, Luminal B, HER2-positive, Triple-negative. Thedisease free survival (DFS) and overall survival (OS) were identified. <br/><b>Results</b>: The 5-year DFS and OS rateswere significantly lower in age<35 than in age≥35 patients. In the Luminal B, HER2-positive, Triple-negativegroup, the 5-year recurrence risk was higher in age<35 than in age≥35 patients, and age<35 patients’ 5-yeardeath risk was higher only in Luminal B, Triple-negative group. Regardless of whether lymph node involved,age<35 patients had a bad prognosis in both DFS and OS. <br/><b>Conclusions</b>: Compared with premenopausal age ≥35breast cancer, age<35 patients had a worse outcome.