Impact of Postoperative Chemoradiotherapy and Chemoradiotherapy Alone for Esophageal Cancer in North-West Iran

Abstract

<b>Background:</b> To investigate the role of surgical treatment for locally advanced esophageal cancer, we comparedthe outcomes of chemoradiotheroy alone (CRT) to postoperative chemoradiotherapy (S/CRT), using, RegionalRadiotherapy Center, database. Materials and <br/><b>Methods</b>: This retrospective study was conducted in North-Westof Iran, included of 255 consecutive patients with esophageal cancer. Eligible operable and non-operable, weretreated with S/CRT and CRT respectively. Radiotherapy (RT) was delivered at 1.8-2 Gy/day for five consecutivedays in a given week. Chemotherapy (CT) consisted of cisplatin and 5-fluorouracil. <br/><b>Results</b>: From March 2006to March 2011 255 patients: male/female 129/96, median age 68 (35-90), squamous/adeno 213/12, received CRT/S+CRT 166/59, median radiation dose 45±13.6Gy, Median survival 13.5 (11-15), overall survival (OS) One/Two/Three 57/21/16%, Died/alive 158/97, Univariate analysis prognostic factors: age/stag/differentiation/dose ofRT/fraction/treatment, Multivariate analysis predictor factor: dose of RT/fraction. <br/><b>Conclusions</b>: Although thistreatment offers some possibility for improvement of patients with esophageal cancer, there remains a significantneed for development of new drug and new therapeutic approaches that can substantially impact survival.