Phase Ⅱ Study on Breast Conservative Surgery Plus Chemoand Radiotherapy in Treating Chinese Patients with Early Staged Breast Cancer

Abstract

Purpose: To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients withearly stage breast cancer. Patients and <br/><b>Methods</b>: Eligible patients were treated by postoperative chemotherapyas well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV wholebreast linear accelerator irradiation with two tangential half fields to a total dose of 45~50 Gy, followed by10~15MeVβ boost irradiation to tumor bed for 10~20Gy, total dose 56~66Gy. <br/><b>Results</b>: Fifty-two patients wereenrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a localrecurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients. <br/><b>Conclusions</b>:Breast conservative surgery combined with chemo- radio-therapy could be a treatment option for Chinesepatients with early stage breast cancer.