Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

Abstract

<br /><strong>Objectives</strong>: Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate.We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Hanpopulation in Southwestern China. <br /><strong>Methods</strong>: We enrolled 308 pairs of GC and control subjects from four hospitalsand a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographicinformation was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphismswere determined by Sequenom MassARRAY analysis. <br /><strong>Results</strong>: Patients with GC reported statistically higherproportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%,P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients andcontrols (PC and IL10-1082 A>G were not associated withoverall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysisshowed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjustedOR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established fromtwo polymorphisms and risk of non-cardia GC. <br /><strong>Conclusions</strong>: In conclusion, our data do not link the two SNPs ofIL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated withprotective effect against non-cardia GC. Our findings may offer insight into risk associated with the developmentof GC in this region.