6,8-Dihydroxy-7-methoxy-1-methyl-azafluorenone (DMMA), a purified compound from Polyalthia cerasoidesroots, is cytotoxic to various cancer cell lines. The aims of this study were to demonstrate the type of cancercell death ...

MicroRNAs (miRNAs) are small, non-coding RNAs that are critical regulators of various diseases. MicroRNA-20a (miR-20a) and microRNA-203 (miR-203) have previously shown significant alteration in a range of cancers.In this ...

Background: Intraoperative sentinel lymph node biopsy has now become the standard of care for patientswith clinically node negative breast cancer for diagnosis and also in order to determine the need for ...

The activity of Rb proteins is controlled by post-translational modifications, especially through phosphorylation.Acetylation of Rb2/p130 was reported recently in NIH3T3 cells but its physiological relevance in cell cycle ...

AKT1 is a member of the serine/threoine AGC protein kinase family involved in thyroid cancer metabolism,growth, proliferation and survival. It is overexpressed in thyroid tumors. In this study, we designed two AKT1specific ...

Recently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae ...

Background: Despite anti-smoking campaigns, smoking prevalence among Thai males aged 30 or older is high,at around 50%. The purpose of this study was to determine the relationship between smoking and ...

Meta-analyses have shown that microRNA polymorphisms have variable effects in different population. Yet,no meta-analysis investigated the association of two common polymorphisms of miRNA, mir-499 rs3746444polymorphism and ...

We investigated the possible association of interleukin-10 (IL-10) single nucleotide polymorphisms (SNPs)and susceptibility to acute myeloid leukemia (AML) in 115 patients and 137 healthy controls. Genetic analysisof IL-10 ...

Background: Papillary thyroid cancer or papillary thyroid carcinoma (PTC) is the most common thyroidcancer. The fact that it occasionally occurs in women aged 30-40 years old suggests that genetic alterations ...

Background: To explore the role of caveolin-1(CAV-1) gene silencing on MAPK activation in lipopolysaccharide(LPS)-challenged human mammary epithelial cells. Methods: We established ...

In India, cervical cancer is the most common woman-related cancer, followed by breast cancer. The rateof cervical cancer in India is fourth worldwide. Two vaccines, Gardasil and Cervarix, both targeting HPV-16and 18 which ...

Background: Pelvic exenteration is a procedure which includes enbloc resection of pelvic organs followed bysurgical reconstruction. Aims include both cure and palliation but data for pelvic exenteration ...

Objective: To compare the efficacy and complications of chemotherapy and late course three-dimensionalconformal radiotherapy (3DCRT) in treating patients with stage III non-small cell lung cancer (NSCLC). ...

Aim: To compare the efficacy and safety of paclitaxel liposome (Lipusu®) with paclitaxel in combination withtegafur and oxaliplatin in treating patients with advanced gastric cancer. Materials and Methods: ...

Several lines of evidence indicate that cancer is a multistep process. To survey the mechanisms involving genealteration and miRNAs in adrenocortical cancer, we focused on transcriptional factors as a point of penetrationto ...

The glutathione S-transferases (GSTs) are a family of enzymes involved in the detoxification of a wide range of chemicals, including important environmental carcinogens, as well as chemotherapeutic agents. In the present ...

Background: To compare the dosimetric coverage of target volumes and organs at risk in the radicaltreatment of nasopharyngeal carcinoma (NPC) between intensity-modulated radiotherapy (IMRT) and ...

Objective: To investigate the expression level of TUG1 and one of its transcript variants (n377360) inosteosarcoma cells and assess the role of TUG1 in proliferation and apoptosis in the U2OS cell ...