Ornithine Decarboxylase: A Promising and Exploratory Candidate Target for Natural Products in Cancer Chemoprevention

Abstract

Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthesis, plays an important role intumor progression, cell proliferation and differentiation. In recent years, ODC has been the subject of intensestudy among researchers, as a target for anti-cancer therapy and specific inhibitory agents, have the potentialto suppress carcinogenesis and find applications in clinical therapy. In particular, it is suggested that ODC is apromising candidate target for natural products in cancer chemoprevention. Future exploration of ornithinedecarboxylase inhibitors present in nature may offer great hope for finding new cancer chemopreventive agents.