Houttuynia cordata Thunb (HCT) is a native herb found in Southeast Asia which features variouspharmacological activities against allergy, inflammation, viral and bacterial infection, and cancer. The aims ofthis study were ...

Bladder cancer is a common malignancy worldwide. Despite the increased use of cisplatin-based combinationtherapy, the outcomes for patients with advanced disease remain poor. Recently, altered activation of the PI3K/Akt/mTOR ...

Background: Ethnic variation in tumor characteristics and clinical presentation of breast cancer is increasinglybeing emphasized. We studied the tumor characteristics and factors which may influence the presentation ...

Background: Health risks associated with unhealthy behaviours in adolescent and university studentscontribute to the development of health problems in later life. During the past twenty years, there has been adramatic ...

Background: To assess the diagnostic potential of tumor-associated high molecular weight DNA in stoolsamples of 32 colorectal cancer (CRC) patients compared to 32 healthy Malaysian volunteers by means ofpolymerase ...

Macrophage migration inhibitory factor (MIF) is a pluripotent cytokine which plays roles in inflammation,immune responses and cancer development. It assists macrophages in carrying out functions like phagocytosis,adherence ...

Objective: To investigate the effect of down-regulation of Sentrin/SUMO-specific protease 1 (SENP1)expression on the apoptosis of human Burkitt lymphoma cells (Daudi cells) and potential mechanisms. ...

Since there is evidence that human papillomavirus (HPV) may play some role in oral carcinogenesis, weinvestigated the presence of HPV in a group of Pakistani subjects with normal oral cavity using real-time PCRanalysis. ...

Sulforaphane (SFN) an isothiocyanate formed by hydrolysis of glucosinolates found in Brassica oleraceaeis reported to possess anticancer and antioxidant activities. In this study, we isolated SFN from red cabbage(Brassica ...

Multidrug resistance (MDR) is a main cause of failure in the chemotherapeutic treatment of malignantdisorders. One of the well-known genes responsible for drug resistance encodes the multidrug resistanceassociatedprotein ...

Background: In spite of the fact that platinum-based doublets are considered the standard therapy for patientswith advanced non-small-cell lung cancer (NSCLC), no elderly-specific platinum based prospective phase ...

Objectives: Recent data show that the metabolic syndrome may play a role in several cancers, but theetiology for biliary tract cancer is incompletely defined. The present aim was to evaluate risk factors for ...

Aim: To investigate the expression of three components of the Hedgehog (Hh) signaling pathway (SHH,SMO and GLI1) in human colorectal cancer (CRC) tissues and evaluate their association with clinicopathologiccharacteristics ...

Pinocembrin (5, 7-dihydroxyflavanone) is a flavanone extracted from the rhizome of Boesenbergia pandurata.Our previous studies demonstrated that pinocembrin had no toxicity or mutagenicity in rats. We here evaluatedits ...

This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphismin p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism inhOGG1 and Arg/Pro ...

Immigration to a nation with a stronger anti-smoking environment has been hypothesized to make smokingless common. However, little is known about how environments influence risk of smoking across the lifecourse.Research ...

Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer(BC). G and breast cancer(BC). Methods: Electronic searches of several databases were conducted for all online ...

The Wiskott-Aldrich Syndrome Protein family Verprolin - homologous proteins (WAVEs), encoded by ametastasis promoter gene, play considerable roles in adhesion of immune cells, cell proliferation, migration anddestruction ...

Purpose: E-cadherin is a transmemberane protein which is responsible for adhesion of endothelial cells. Theaim of our study was to assess existing evidence of associations between reduced expression of E-cadherin andprognosis ...

Introduction: Worldwide, breast cancer is the commonest cause of cancer death in women. However, thesurvival rate varies across regions at averages of 73%and 57% in the developed and developing countries,respectively. ...