The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

Abstract

<br/><b>Objective</b>: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer(BC). <br/><b>Methods</b>: Electronic searches of several databases were conducted for all online publications. A total of 7studies involving 4,625 BC patients and 4,373 controls were identified. <br/><b>Results</b>: This meta-analysis showed nosignificant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations.However, a positive association was found limited to Asian populations. <br/><b>Conclusion</b>: Although there was nosignificant association found between the LTA-252 A>G polymorphism and BC overall, a positive associationwas found in Asian populations.