Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid

Abstract

Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targetsof breast tumor cells is an attractive goal towards improving clinical treatment. The present study showedthat CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. Inaddition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDAMB-231cells ,with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppressthe phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate thatPA could inhibit breast cancer metastasis via PITPNM3.