Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
(ندگان)پدیدآور
Guven, MustafaBozkurt Aras, AdemAkman, TarikMurat Sen, HalilOzkan, AdileSalis, OsmanSehitoglu, IbrahimKalkan, YildiraySilan, CoskunDeniz, MustafaCosar, Muratنوع مدرک
TextOriginal Article
زبان مدرک
Englishچکیده
Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats.
Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores.
Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia.
Conclusion:Our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
کلید واژگان
ApoptosisCoumaric acids
Ischemia
Neuroprotective agents
Nuclear respiratory factor 1
Rats
شماره نشریه
4تاریخ نشر
2015-04-011394-01-12
ناشر
Mashhad University of Medical Sciencesسازمان پدید آورنده
Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, TurkeyDepartment of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
Department of Pathology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey
Department of Histology & Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey
Department of Pharmacology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Physiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
شاپا
2008-38662008-3874