Iranian Journal of Basic Medical Sciences

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ارسال های اخیر

Retracted: Gallic acid from Terminalia chebula inhibited the growth of esophageal carcinoma cells by suppressing the Hippo signal pathway

پدیدآور نامشخص (Mashhad University of Medical Sciences, 2025-08-01)
Verbenone prevents cyclophosphamide-induced oxidative stress, inflammation, fibrosis, and cellular changes in the kidneys of Swiss albino mice by targeting NF-ĸB/TGF-β signaling pathways

Wasim, Mohd؛ Ali, Syed؛ Haque, Syed (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Verbenone was assessed for its protective effect in cyclophosphamide-induced nephrotoxicity in Swiss albino mice. Materials and Methods: Mice were divided into six groups (n = 6). Vehicle Control, CP 200, VRB ...
Testicular extracellular matrix/gelatin-based scaffold using gas foaming to support spermatogonial stem cells

Momeni, Maryam؛ Kazemi Ashtiani, Mohammad؛ Bashiri, Zahra؛ Bagher, Zohreh؛ Asgari, Hamid Reza؛ Koruji, Morteza (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Developing a bioactive testicular scaffold has been proposed as a potential option to preserve male fertility. Using the gas foaming method, this study aimed to fabricate an effective and highly porous scaffold ...
Hepatoprotective effects of Curcuma xanthorrhiza Roxb. extract via free radical scavenger, inhibiting apoptosis and inflammation mechanisms in acetaminophen-induced liver injury

Lister, I Nyoman؛ Chiuman, Linda؛ Mutia, Maya؛ Hartono, Hartono؛ Girsang, Ermi؛ Sutendi, Annisa؛ Kusuma, Hanna؛ Hadiprasetyo, Dhanar؛ Widowati, Wahyu (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Acetaminophen (APAP)-mediated liver injury poses a significant public health concern. Curcuma xanthorrhiza extract (CXE) has been traditionally used for its hepatoprotective properties. This research aimed ...
Comparison of cellular, mechanical, and optical properties of different polymers for corneal tissue engineering

Zamani, Sepehr؛ Javad, Sadeghi؛ Kamalabadi-Farahani, Mohammad؛ Aghayan, Seyede Nazanin؛ Arabpour, Zohreh؛ Djalilian, Ali؛ Salehi, Majid (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): The invention of corneal tissue engineering is essential for vision due to the lack of effective treatments and donated corneas. Finding the right polymer is crucial for reducing inflammation, ensuring ...
Down-regulation of Neuregulin2 (NRG2) following spinal cord injury in C57BL/6 mice: Its implications in therapeutic potential

Hua, Kai-Ye؛ Liu, Yan-Jun؛ Ke, Qi؛ Song, Quan؛ Zhang, Shuai؛ Zhao, Wei-Jiang (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): This study aims to elucidate the alterations in Neuregulin 2 (NRG2) and its receptor ErbB4 following spinal cord injury (SCI), as well as to investigate the neuroprotective mechanisms of NRG2 in neurons. Materials ...
Mitotherapy attenuates sepsis-induced brain injury in rats subjected to cecal ligation and puncture: Role of SIRT-1/PGC-1α network

Mokhtari, Behnaz؛ Alihemmati, Alireza؛ Bafadam, Soleyman؛ Boraghi, Solmaz؛ Badalzadeh, Reza؛ Mahmoodpoor, Ata (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Sepsis-induced brain injury poses a critical challenge with limited therapeutic options. Mitochondrial dysfunction is a central contributor to this pathogenesis. The current work aimed to examine the effects ...
Therapeutic potential of casticin in alleviating ovarian torsion/detorsion-induced ovarian and lung injuries

Eraslan, Ersen؛ Tanyeli̇, Ayhan؛ Guler, Mustafa؛ Eki̇nci̇ Akdemi̇r, Fazile Nur؛ Topdaği, Ömer؛ Yazici, Şahin؛ Güzel Erdoğan, Derya؛ Çinar Tanriverdi̇, Esra؛ Çomakli, Selim (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion ...
Nanoencapsulation of B-toxin from herbal extracts: Targeting HTLV-1 protease and ATLL

Baghban, Arezoo؛ Momen Heravi, Mohammad؛ Rezaee, Seyed Abdolrahim؛ Tafaghodi, Mohsen؛ Bozorgmehr, Mohammadreza (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Toxin B and isotoxin B (TB, isoTB) are major constituents of the Taxus baccata tree. This study investigates the inhibitory effect of TB and isoTB on adult T-cell leukemia/lymphoma (ATLL), particularly on ...
PorelisTM, a standardized purple tea extract, improves adipocyte functionality by regulating the leptin and adiponectin levels in high-fat diet-induced C57Bl/6 mice

Sudeep, Heggar؛ Sundeep, Kuppam؛ Venkatakrishna, Karempudi؛ Raj, Amrutha؛ Bhumika, Ranganath؛ Prasanna Kumar, Thammatadhahalli Parameshwarappa؛ Shyamprasad, Kodimule (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Purple tea variety of Camelia sinensis (L.) Kuntze (Theaceae), with its unique presence of anthocyanins and 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-β-D-glucose (GHG), has enormous potential in the ...
Mitochondrial protection and anti-inflammatory effect of curcumin in inhibiting reproductive toxicity induced by sodium valproate in male mice

Shaneh, Moein؛ Chahardori, Milad؛ Talebpour Amiri, Fereshteh؛ Amani, Nahid؛ Shaki, Fatemeh (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Sodium valproate (VPA) has harmful effects on the male reproductive system. The present study aimed to investigate the influence of curcumin (CUR) in mitigating the VPA-induced reproductive toxicity in male ...
Gypenosides alleviates MCT-induced pulmonary arterial hypertension in rats by targeting oxidative stress, inflammation, and apoptosis

Dan, Du؛ Gong, Xiao-Wei؛ Yuan, Ya-Dong (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Pulmonary arterial hypertension (PAH) is a severe heart-lung condition characterized by complex changes in the pulmonary vasculature, known as pulmonary vascular remodeling (PVR). Gypenosides (Gyp) possesses ...
Anti-obesity and hepatoprotective effects of pyridoxal phosphate in rats with metabolic syndrome by raising anti-oxidant potential in both serum and liver tissue, while also decreasing hepatic nuclear factor expression

Mahdavifard, Sina؛ Hasani, Amir (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Insulin resistance is the primary trigger of metabolic syndrome, carbonyl stress, and vitamin B6 deficiency, while the nuclear factor (NF-κB) pathway is a pivotal factor in its development. Hence, we investigated ...
Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats

Gu, Haiping؛ Gong, Yating؛ Wu, Muyao؛ Shi, Mengying؛ Yu, Jiejie؛ Zhu, Hongfei؛ Sun, Ya-ming؛ Dang, Baoqi (Mashhad University of Medical Sciences, 2025-08-01)

Objective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions. ...
Effect of Crocus sativus L. (saffron) and Rosmarinus officinalis L. (rosemary) in hepatocellular carcinoma: A narrative review of current evidence and prospects

Naraki, Gol Afrouz؛ Fazeli Kakhki, Homa؛ Qoorchi Moheb Seraj, Farid؛ Naraki, Karim؛ Ghasemzadeh Rahbardar, Mahboobeh (Mashhad University of Medical Sciences, 2025-08-01)

Hepatocellular carcinoma (HCC) is a considerable worldwide health concern that requires novel therapeutic approaches. Herbal therapy, with its rich historical origins and diverse pharmacological properties, provoked interest ...
Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies

Javad Saadh, Mohamed؛ Qahtan, Sarraa Ahmad؛ Albadr, Rafid Jihad؛ Sanghvi, Gaurav؛ Roopashree, Rangaswamy؛ Kashyap, Aditya؛ Sabarivani, A.؛ Rizaev, Jasur؛ Taher, Waam Mohammed؛ Alwan, Mariem؛ Jawad, Mahmod Jasem؛ M. Ali Al-Nuaimi, Ali (Mashhad University of Medical Sciences, 2025-08-01)

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide ...
Corrigendum: Anticancer activity of Pseudomonas aeruginosa derived peptide with iRGD in colon cancer therapy

پدیدآور نامشخص (Mashhad University of Medical Sciences, 2025-07-01)
Troxerutin alleviates hepatorenal toxicity induced by carbon tetrachloride in male mice

Hakimizadeh, Elham؛ Kaeidi, Ayat؛ Fatemi, Iman؛ Shamsizadeh, Ali؛ Hassanshahi, Jalal (Mashhad University of Medical Sciences, 2025-07-01)

Objective(s): Troxerutin (TRX) is a natural bioflavonoid with several medicinal properties. We assessed its protective effect on carbon tetrachloride-related hepatorenal damage in male mice.Materials and Methods: Male mice ...
Schisandrin B regulates the SIRT1/PI3K/Akt signaling pathway to ameliorate Ang II-infused cardiac fibrosis

Zhang, Xiaogang؛ Shi, Mengqing؛ Xing, Zhongying؛ Su, Jie؛ Gu, Yuying؛ Ning, Zhongping (Mashhad University of Medical Sciences, 2025-07-01)

Objective(s): Schisandrin B (SchB), extracted from Schisandra chinensis, has antimicrobial and anti-inflammatory effects. The study aimed to investigate SchB's possible defense against angiotensin II (Ang II)-infused cardiac ...
Effect of chitosan nanoparticles loaded with platelet lysate on in vitro fertilization and early embryo development in a mouse premature ovarian failure model

Torabi, Fereshte؛ Karimi, Sareh؛ Alipour, Fatemeh؛ Mirzaei-Parsa, Mohamad Javad؛ Ebrahimzadeh-Bideskan, Alireza (Mashhad University of Medical Sciences, 2025-07-01)

Objective(s): Premature ovarian failure (POF) is a common cause of women's infertility. Cyclophosphamide (CP) is one of the most important gonadotoxic agents that lead to POF. This study aimed to evaluate the potential ...