Systematic Analysis on the GSTM1 Null Phenotype and Prostate Cancer Risk in Chinese People

Abstract

<br/><b>Objective</b>: Glutathione S-transferase M 1 (GSTM1) is implicated as a risk factor for prostate cancer.However, this issue is not clear in Chinese population. This systemic analysis was conducted to evaluate theeffect of GSTM1 null genotypes on prostate cancer risk in Chinese. <br/><b>Methods</b>: Published studies investigating theassociations between GSTM1 null genotypes and the risk of prostate cancer in China were identified by using apredefined search strategy. Main statisticals were pooled and estimated according to the primarily reported data.<br/><b>Results</b>: The prevalence of the GSTM1 null genotype was higher in prostate cancer patients than in controls,with significance. <br/><b>Conclusion</b>: The GSTM1 null genotypes is associated with increased risk of prostate cancerin Chinese.