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      مشاهده مورد 
      •   صفحهٔ اصلی
      • نشریات انگلیسی
      • Asian Pacific Journal of Cancer Prevention
      • Volume 16, Issue 5
      • مشاهده مورد
      •   صفحهٔ اصلی
      • نشریات انگلیسی
      • Asian Pacific Journal of Cancer Prevention
      • Volume 16, Issue 5
      • مشاهده مورد
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      Irinotecan as a Second-line Chemotherapy for Small Cell Lung Cancer: a Systemic Analysis

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      زبان مدرک
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      چکیده
      Purpose: This analysis was conducted to evaluate the efficacy and safety of irinotecan based regimens assecond-line chemotherapy in treating patients with small cell lung cancer. Methods: Clinical studies evaluatingthe efficacy and safety of irinotecan based regimens as second-line chemotherapy for patients with small celllung cancer were identified using a predefined search strategy. Pooled response rates (RRs) of treatment werecalculated. Results: In irinotecan based regimens as second-line chemotherapy, 4 clinical studies which including155 patients with small cell lung cancer were considered eligible for inclusion. In all chemotherapy consistedof irinotecan with or without nedaplatin. Pooled analysis suggested that, in all patients, the pooled RR was27.1% (42/155) in irinotecan based regimens. Nausea, vomiting, diarrhea and myelosuppression were the mainside effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred withthe irinotecan based treatments. Conclusion: This systemic analysis suggests that irinotecan based regimens assecond-line chemotherapy are associated with mild response rate and acceptable toxicity for patients with smallcell lung cancer.
      کلید واژگان
      Irinotecan
      second-line chemotherapy
      small cell lung cancer

      شماره نشریه
      5
      تاریخ نشر
      2015-05-01
      1394-02-11
      ناشر
      West Asia Organization for Cancer Prevention (WAOCP)

      شاپا
      1513-7368
      2476-762X
      URI
      http://journal.waocp.org/article_30696.html
      https://iranjournals.nlai.ir/handle/123456789/33976

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