مرور Volume 20, Issue 9 بر اساس عنوان
در حال نمایش موارد 1 - 13 از 13
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Apatinib has anti-tumor effects and induces autophagy in colon cancer cells
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Apatinib recently has been used to treat patients with gastric cancer, but the function of apatinib in colon cancer remains unclear. This study was conducted to investigate the impacts ...
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Calycosin attenuates dextran sulfate sodium (DSS)-induced experimental colitis
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s):Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. ...
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Cancer/Testis genes in relation to sperm biology and function
(Mashhad University of Medical Sciences, 2017-09-01)Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been ...
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The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is ...
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Effects of mild hypothermia on expression of NF-E2-related factor 2 and heme-oxygenase-1 in cerebral cortex and hippocampus after cardiopulmonary resuscitation in rats
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): The aim of this study was to investigate the effects of mild hypothermia on expression of NF-E2-related factor 2 (Nrf2) and heme-oxygenase-1 (HO-1) of rat cerebral cortex and hippocampus ...
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Evaluation of bax, bcl-2, p21 and p53 genes expression variations on cerebellum of BALB/c mice before and after birth under mobile phone radiation exposure
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): The increasing rate of over using cell phones has been considerable in youths and pregnant women. We examined the effect of mobile phones radiation on genes expression variation on ...
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Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effectson the central nervous system. Thus, this study was designed to ...
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Prenatal exposure to TAK242 affects the childhood autism in offspring in animal models of autism spectrum disorder
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): To evaluate whether prenatal exposure to TAK242 affects childhood autism in the offspring in animal models of autism spectrum disorder (ASD). Materials and ...
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Presenting a rapid method for detection of Bacillus cereus, Listeria monocytogenes and Campylobacter jejuni in food samples
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Listeria monocytogens, Bacillus cereus and Campylobacter jejuni are three toxin producing bacteria over the world, especially in Iran, and it is essential ...
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Regulation of autophagy by AMP-activated protein kinase/ sirtuin 1 pathway reduces spinal cord neurons damage
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): AMP-activated protein kinase/sirtuin 1 (AMPK/SIRT1) signaling pathway has been proved to be involved in the regulation of autophagy in various models. The aim of this study was to ...
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shRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine ...
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Synthesis, characterization, molecular docking studies and biological evaluation of some novel hybrids based on quinazolinone, benzofuran and imidazolium moieties as potential cytotoxic and antimicrobial agents
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Hybridization of bioactive natural and synthetic compounds is one of the most promising novel approaches for the design of hit and lead compounds with new molecular structures. In ...
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Therapeutic potential of genistein in ovariectomy-induced pancreatic injury in diabetic rats: The regulation of MAPK pathway and apoptosis
(Mashhad University of Medical Sciences, 2017-09-01)Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of ...
