مرور Volume 23, Issue 6 بر اساس تاریخ انتشار
در حال نمایش موارد 1 - 11 از 11
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Prenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Stress during pregnancy is able to bring extensive effects on neurobehavioral development in offspring. The GABAergic system plays a pivotal role in neuronal excitability, which can ...
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The effects of synthetic orally administrated insulin nanoparticles in comparison to injectable insulin on the renal function markers of type 1- diabetic rats
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Injectable insulin is the most widely used therapy in patients with type 1 diabetes which has several disadvantages. The present study was aimed to evaluate the efficacy of injectable ...
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Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative ...
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The effect of different pulp-capping materials on proliferation, migration and cytokine secretion of human dental pulp stem cells
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Biocompatibility of dental biomaterials plays a critical role in regeneration of dental stem cells. The aim of present study was to evaluate the effects of novel biomaterials of ...
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Chitosan-based nano-scaffolds as antileishmanial wound dressing in BALB/c mice treatment: Characterization and design of tissue regeneration
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Rapid healing of cutaneous leishmaniasis as one of the most important parasitic diseases leads to the decrease of scars and prevention of a great threat to the looks of the affected ...
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Wi-Fi (2.4 GHz) affects anti-oxidant capacity, DNA repair genes expression and apoptosis in pregnant mouse placenta
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): The placenta provides nutrients and oxygen to embryo and removes waste products from embryo's blood. As far as we know, the effects of exposure to Wi-Fi (2.4 GHz) signals on placenta ...
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Soluble uric acid induces inflammation via TLR4/NLRP3 pathway in intestinal epithelial cells
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. ...
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Ameliorative effects of histidine on oxidative stress, tumor necrosis factor alpha (TNF-α), and renal histological alterations in streptozotocin/nicotinamide-induced type 2 diabetic rats
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): The present study sought to evaluate the beneficial effects of histidine (His) on oxidative stress, tumor necrosis factor alpha (TNF-α), renal histological alterations and anti-oxidant ...
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Simvastatin combined with bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis through SDF-1α/CXCR4 pathway
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Chemokines are wound mediators that promote angiogenesis during wound healing. We hypothesized that Simvastatin in combination with the bone marrow mesenchymal stromal cells (BMSCs) ...
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Construction and assessment of the immunogenicity and bactericidal activity of fusion protein porin A from <i>Neisseria meningitidis</i> serogroups A and B admixed with OMV adjuvant as a novel vaccine candidate
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): The porins A and B and also outer membrane vesicles (OMVs) of Neisseria meningitidis are used for vaccine purposes. In the present study, we aimed to design a new vaccine candidate ...
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<i>Nigella sativa</i>: Valuable perspective in the management of chronic diseases
(Mashhad University of Medical Sciences, 2020-06-01)Objective(s): Over the past 20 years, increasing interest in the use of medicinal plants as alternative or adjuvant treatments of several chronic diseases was observed. Accordingly, Nigella sativa ...
